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IView: introgression library visualization and query tool

BACKGROUND: An introgression library is a family of near-isogenic lines in a common genetic background, each of which carries one or more genomic regions contributed by a donor genome. Near-isogenic lines are powerful genetic resources for the analysis of phenotypic variation and are important for m...

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Detalles Bibliográficos
Autores principales: Bottoms, Christopher A, Flint-Garcia, Sherry, McMullen, Michael D
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026375/
https://www.ncbi.nlm.nih.gov/pubmed/20946612
http://dx.doi.org/10.1186/1471-2105-11-S6-S28
Descripción
Sumario:BACKGROUND: An introgression library is a family of near-isogenic lines in a common genetic background, each of which carries one or more genomic regions contributed by a donor genome. Near-isogenic lines are powerful genetic resources for the analysis of phenotypic variation and are important for map-base cloning genes underlying mutations and traits. With many thousands of distinct genotypes, querying introgression libraries for lines of interest is an issue. RESULTS: We have created IView, a tool to graphically display and query near-isogenic line libraries for specific introgressions. This tool incorporates a web interface for displaying the location and extent of introgressions. Each genetic marker is associated with a position on a reference map. Users can search for introgressions using marker names, or chromosome number and map positions. This search results in a display of lines carrying an introgression at the specified position. Upon selecting one of the lines, color-coded introgressions on all chromosomes of the line are displayed graphically. The source code for IView can be downloaded from http://xrl.us/iview. CONCLUSIONS: IView will be useful for those wanting to make introgression data from their stock of germplasm searchable.