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Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments

Rosette nanotubes (RNTs) are novel, biomimetic, injectable, self-assembled nanomaterials. In previous studies, materials coated with RNTs have significantly increased cell growth (eg, osteoblasts, chondrocytes, and endothelial cells) due to the favorable cellular environment created by RNTs. It has...

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Detalles Bibliográficos
Autores principales: Song, Shang, Chen, Yupeng, Yan, Zhimin, Fenniri, Hicham, Webster, Thomas J
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026575/
https://www.ncbi.nlm.nih.gov/pubmed/21289987
http://dx.doi.org/10.2147/IJN.S11957
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author Song, Shang
Chen, Yupeng
Yan, Zhimin
Fenniri, Hicham
Webster, Thomas J
author_facet Song, Shang
Chen, Yupeng
Yan, Zhimin
Fenniri, Hicham
Webster, Thomas J
author_sort Song, Shang
collection PubMed
description Rosette nanotubes (RNTs) are novel, biomimetic, injectable, self-assembled nanomaterials. In previous studies, materials coated with RNTs have significantly increased cell growth (eg, osteoblasts, chondrocytes, and endothelial cells) due to the favorable cellular environment created by RNTs. It has also been suggested that the tubular RNT structures formed by base stacking and hydrophobic interactions can be used for drug delivery, and this possibility has not been studied to date. Here we investigated methods to load and deliver tamoxifen (TAM, a hydrophobic anticancer drug) using two different types of RNTs: single- base RNTs and twin-base RNTs. Drug-loaded RNTs were characterized by nuclear magnetic resonance spectroscopy, diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY NMR), and ultraviolet-visible (UV-Vis) spectroscopy at different ratios of twin-base RNTs to TAM. The results demonstrated successful incorporation of hydrophobic TAM into RNTs. Importantly, because of the hydrophilicity of the outer surface of the RNTs, TAM-loaded RNTs were dissolved in water, and thus have great potential to deliver hydrophobic drugs in various physiological environments. The results also showed that twin-base RNTs further improved TAM loading. Therefore, this study demonstrated that hydrophobic pharmaceutical agents (such as TAM), once considered hard to deliver, can be easily incorporated into RNTs for anticancer treatment purposes.
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spelling pubmed-30265752011-02-02 Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments Song, Shang Chen, Yupeng Yan, Zhimin Fenniri, Hicham Webster, Thomas J Int J Nanomedicine Original Research Rosette nanotubes (RNTs) are novel, biomimetic, injectable, self-assembled nanomaterials. In previous studies, materials coated with RNTs have significantly increased cell growth (eg, osteoblasts, chondrocytes, and endothelial cells) due to the favorable cellular environment created by RNTs. It has also been suggested that the tubular RNT structures formed by base stacking and hydrophobic interactions can be used for drug delivery, and this possibility has not been studied to date. Here we investigated methods to load and deliver tamoxifen (TAM, a hydrophobic anticancer drug) using two different types of RNTs: single- base RNTs and twin-base RNTs. Drug-loaded RNTs were characterized by nuclear magnetic resonance spectroscopy, diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY NMR), and ultraviolet-visible (UV-Vis) spectroscopy at different ratios of twin-base RNTs to TAM. The results demonstrated successful incorporation of hydrophobic TAM into RNTs. Importantly, because of the hydrophilicity of the outer surface of the RNTs, TAM-loaded RNTs were dissolved in water, and thus have great potential to deliver hydrophobic drugs in various physiological environments. The results also showed that twin-base RNTs further improved TAM loading. Therefore, this study demonstrated that hydrophobic pharmaceutical agents (such as TAM), once considered hard to deliver, can be easily incorporated into RNTs for anticancer treatment purposes. Dove Medical Press 2011 2011-01-10 /pmc/articles/PMC3026575/ /pubmed/21289987 http://dx.doi.org/10.2147/IJN.S11957 Text en © 2011 Song et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Song, Shang
Chen, Yupeng
Yan, Zhimin
Fenniri, Hicham
Webster, Thomas J
Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_full Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_fullStr Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_full_unstemmed Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_short Self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
title_sort self-assembled rosette nanotubes for incorporating hydrophobic drugs in physiological environments
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026575/
https://www.ncbi.nlm.nih.gov/pubmed/21289987
http://dx.doi.org/10.2147/IJN.S11957
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