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Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer
Understanding the progression of a primary cancer to the metastatic stage has been the focus of extensive research for years. Commonly accepted concepts in this process (i.e., that of genetic instability and loss of normal cellular constraints on growth and motility) are well established. Other impo...
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Formato: | Texto |
Lenguaje: | English |
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Faculty of 1000 Ltd
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026620/ https://www.ncbi.nlm.nih.gov/pubmed/21283595 http://dx.doi.org/10.3410/B2-86 |
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author | Gavert, Nancy Ben-Ze'ev, Avri |
author_facet | Gavert, Nancy Ben-Ze'ev, Avri |
author_sort | Gavert, Nancy |
collection | PubMed |
description | Understanding the progression of a primary cancer to the metastatic stage has been the focus of extensive research for years. Commonly accepted concepts in this process (i.e., that of genetic instability and loss of normal cellular constraints on growth and motility) are well established. Other important paradigms, such as the necessary change from an epithelial cell phenotype displaying cell-cell adhesions to a singular and motile mesenchymal-like cell phenotype (possibly derived from a stem cell-like cell) via a process similar to epithelial to mesenchymal transition (EMT), are less well understood. In this review we will address studies linking EMT and cancer stem cells during cancer development and observations that are challenging these concepts. |
format | Text |
id | pubmed-3026620 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Faculty of 1000 Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-30266202011-01-31 Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer Gavert, Nancy Ben-Ze'ev, Avri F1000 Biol Rep Review Article Understanding the progression of a primary cancer to the metastatic stage has been the focus of extensive research for years. Commonly accepted concepts in this process (i.e., that of genetic instability and loss of normal cellular constraints on growth and motility) are well established. Other important paradigms, such as the necessary change from an epithelial cell phenotype displaying cell-cell adhesions to a singular and motile mesenchymal-like cell phenotype (possibly derived from a stem cell-like cell) via a process similar to epithelial to mesenchymal transition (EMT), are less well understood. In this review we will address studies linking EMT and cancer stem cells during cancer development and observations that are challenging these concepts. Faculty of 1000 Ltd 2010-12-08 /pmc/articles/PMC3026620/ /pubmed/21283595 http://dx.doi.org/10.3410/B2-86 Text en © 2010 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes |
spellingShingle | Review Article Gavert, Nancy Ben-Ze'ev, Avri Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer |
title | Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer |
title_full | Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer |
title_fullStr | Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer |
title_full_unstemmed | Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer |
title_short | Coordinating changes in cell adhesion and phenotype during EMT-like processes in cancer |
title_sort | coordinating changes in cell adhesion and phenotype during emt-like processes in cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026620/ https://www.ncbi.nlm.nih.gov/pubmed/21283595 http://dx.doi.org/10.3410/B2-86 |
work_keys_str_mv | AT gavertnancy coordinatingchangesincelladhesionandphenotypeduringemtlikeprocessesincancer AT benzeevavri coordinatingchangesincelladhesionandphenotypeduringemtlikeprocessesincancer |