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Temporal requirements of insulin/IGF-1 signaling for proteotoxicity protection

Toxic protein aggregation (proteotoxicity) is a unifying feature in the development of late-onset human neurodegenerative disorders. Reduction of insulin/IGF-1 signaling (IIS), a prominent lifespan, developmental and reproductive regulatory pathway, protects worms from proteotoxicity associated with...

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Detalles Bibliográficos
Autores principales:	Cohen, Ehud, Du, Deguo, Joyce, Derek, Kapernick, Erik A, Volovik, Yuli, Kelly, Jeffery W, Dillin, Andrew
Formato:	Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2010
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026833/ https://www.ncbi.nlm.nih.gov/pubmed/20003171 http://dx.doi.org/10.1111/j.1474-9726.2009.00541.x

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