Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans

The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recog...

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Autores principales: Marakalala, Mohlopheni J., Kerrigan, Ann M., Brown, Gordon D.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026934/
https://www.ncbi.nlm.nih.gov/pubmed/20700596
http://dx.doi.org/10.1007/s00335-010-9277-3
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author Marakalala, Mohlopheni J.
Kerrigan, Ann M.
Brown, Gordon D.
author_facet Marakalala, Mohlopheni J.
Kerrigan, Ann M.
Brown, Gordon D.
author_sort Marakalala, Mohlopheni J.
collection PubMed
description The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease.
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spelling pubmed-30269342011-02-22 Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans Marakalala, Mohlopheni J. Kerrigan, Ann M. Brown, Gordon D. Mamm Genome Article The clinical relevance of fungal infections has increased dramatically in recent decades as a consequence of the rise of immunocompromised populations, and efforts to understand the underlying mechanisms of protective immunity have attracted renewed interest. Here we review Dectin-1, a pattern recognition receptor involved in antifungal immunity, and discuss recent discoveries of polymorphisms in the gene encoding this receptor which result in human disease. Springer-Verlag 2010-08-11 2011 /pmc/articles/PMC3026934/ /pubmed/20700596 http://dx.doi.org/10.1007/s00335-010-9277-3 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Marakalala, Mohlopheni J.
Kerrigan, Ann M.
Brown, Gordon D.
Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
title Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
title_full Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
title_fullStr Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
title_full_unstemmed Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
title_short Dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
title_sort dectin-1: a role in antifungal defense and consequences of genetic polymorphisms in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026934/
https://www.ncbi.nlm.nih.gov/pubmed/20700596
http://dx.doi.org/10.1007/s00335-010-9277-3
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AT kerriganannm dectin1aroleinantifungaldefenseandconsequencesofgeneticpolymorphismsinhumans
AT browngordond dectin1aroleinantifungaldefenseandconsequencesofgeneticpolymorphismsinhumans

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