Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)

Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs...

Descripción completa

Detalles Bibliográficos
Autores principales: Noh, Joonyong, Choi, Wahn Soo, Noh, Geunwoong, Lee, Jae Ho
Formato: Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2010
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026945/
https://www.ncbi.nlm.nih.gov/pubmed/21286386
http://dx.doi.org/10.4110/in.2010.10.6.247
_version_ 1782197103323250688
author Noh, Joonyong
Choi, Wahn Soo
Noh, Geunwoong
Lee, Jae Ho
author_facet Noh, Joonyong
Choi, Wahn Soo
Noh, Geunwoong
Lee, Jae Ho
author_sort Noh, Joonyong
collection PubMed
description Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of 8.5±3.5% of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated.
format Text
id pubmed-3026945
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher The Korean Association of Immunologists
record_format MEDLINE/PubMed
spelling pubmed-30269452011-01-31 Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg) Noh, Joonyong Choi, Wahn Soo Noh, Geunwoong Lee, Jae Ho Immune Netw Brief Communication Foxp3 is a transcript factor for regulatory T cell development. Interestingly, Foxp3-expressing cells were identified in B cells, especially in CD19(+)CD5(+) B cells, while those were not examined in CD19(+)CD5(-) B cells. Foxp3-expressing CD5(+) B cells in this study were identified in human PBMCs and were found to consist of 8.5±3.5% of CD19(+)CD5(+) B cells. CD19(+)CD5(+)Foxp3(+) B cells showed spontaneous apoptosis. Rare CD19(+)CD5(+) Foxp3(+) regulatory B cell (Breg) population was unveiled in human peripheral blood mononuclear cells and suggested as possible regulatory B cells (Breg) as regulatory T cells (Treg). The immunologic and the clinical relevant of Breg needs to be further investigated. The Korean Association of Immunologists 2010-12 2010-12-31 /pmc/articles/PMC3026945/ /pubmed/21286386 http://dx.doi.org/10.4110/in.2010.10.6.247 Text en Copyright © 2010 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Noh, Joonyong
Choi, Wahn Soo
Noh, Geunwoong
Lee, Jae Ho
Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)
title Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)
title_full Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)
title_fullStr Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)
title_full_unstemmed Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)
title_short Presence of Foxp3-expressing CD19(+)CD5(+) B Cells in Human Peripheral Blood Mononuclear Cells: Human CD19(+)CD5(+)Foxp3(+) Regulatory B Cell (Breg)
title_sort presence of foxp3-expressing cd19(+)cd5(+) b cells in human peripheral blood mononuclear cells: human cd19(+)cd5(+)foxp3(+) regulatory b cell (breg)
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026945/
https://www.ncbi.nlm.nih.gov/pubmed/21286386
http://dx.doi.org/10.4110/in.2010.10.6.247
work_keys_str_mv AT nohjoonyong presenceoffoxp3expressingcd19cd5bcellsinhumanperipheralbloodmononuclearcellshumancd19cd5foxp3regulatorybcellbreg
AT choiwahnsoo presenceoffoxp3expressingcd19cd5bcellsinhumanperipheralbloodmononuclearcellshumancd19cd5foxp3regulatorybcellbreg
AT nohgeunwoong presenceoffoxp3expressingcd19cd5bcellsinhumanperipheralbloodmononuclearcellshumancd19cd5foxp3regulatorybcellbreg
AT leejaeho presenceoffoxp3expressingcd19cd5bcellsinhumanperipheralbloodmononuclearcellshumancd19cd5foxp3regulatorybcellbreg

Ejemplares similares