Cargando…

Procalcitonin: A Key Marker in Children with Urinary Tract Infection

Urinary tract infections (UTIs) are the most common source of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN) and vesicoureteral reflux (VUR) is important because of their association with renal scarring, leading in the cases to long-term complicat...

Descripción completa

Detalles Bibliográficos
Autores principales: Leroy, Sandrine, Gervaix, Alain
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026964/
https://www.ncbi.nlm.nih.gov/pubmed/21274426
http://dx.doi.org/10.1155/2011/397618
_version_ 1782197103573860352
author Leroy, Sandrine
Gervaix, Alain
author_facet Leroy, Sandrine
Gervaix, Alain
author_sort Leroy, Sandrine
collection PubMed
description Urinary tract infections (UTIs) are the most common source of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN) and vesicoureteral reflux (VUR) is important because of their association with renal scarring, leading in the cases to long-term complications. However, the gold standard examinations for both are either DMSA scan (for APN and scar) or cystography (for VUR) and present limitations (feasibility, pain, cost, etc.). Procalcitonin, a reliable marker of bacterial infections, was demonstrated to be a good predictor of both renal parenchymal involvement in the acute phase and late renal scars. Furthermore, it was also found to be associated with high-grade VUR and was the key tool of a clinical decision rule to predict high-grade VUR in children with a first UTI. Therefore, procalcitonin may certainly be found playing a role in the complex and still debated picture of which examination should be performed after UTI in children.
format Text
id pubmed-3026964
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-30269642011-01-27 Procalcitonin: A Key Marker in Children with Urinary Tract Infection Leroy, Sandrine Gervaix, Alain Adv Urol Research Article Urinary tract infections (UTIs) are the most common source of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN) and vesicoureteral reflux (VUR) is important because of their association with renal scarring, leading in the cases to long-term complications. However, the gold standard examinations for both are either DMSA scan (for APN and scar) or cystography (for VUR) and present limitations (feasibility, pain, cost, etc.). Procalcitonin, a reliable marker of bacterial infections, was demonstrated to be a good predictor of both renal parenchymal involvement in the acute phase and late renal scars. Furthermore, it was also found to be associated with high-grade VUR and was the key tool of a clinical decision rule to predict high-grade VUR in children with a first UTI. Therefore, procalcitonin may certainly be found playing a role in the complex and still debated picture of which examination should be performed after UTI in children. Hindawi Publishing Corporation 2011 2011-01-17 /pmc/articles/PMC3026964/ /pubmed/21274426 http://dx.doi.org/10.1155/2011/397618 Text en Copyright © 2011 S. Leroy and A. Gervaix. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Leroy, Sandrine
Gervaix, Alain
Procalcitonin: A Key Marker in Children with Urinary Tract Infection
title Procalcitonin: A Key Marker in Children with Urinary Tract Infection
title_full Procalcitonin: A Key Marker in Children with Urinary Tract Infection
title_fullStr Procalcitonin: A Key Marker in Children with Urinary Tract Infection
title_full_unstemmed Procalcitonin: A Key Marker in Children with Urinary Tract Infection
title_short Procalcitonin: A Key Marker in Children with Urinary Tract Infection
title_sort procalcitonin: a key marker in children with urinary tract infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026964/
https://www.ncbi.nlm.nih.gov/pubmed/21274426
http://dx.doi.org/10.1155/2011/397618
work_keys_str_mv AT leroysandrine procalcitoninakeymarkerinchildrenwithurinarytractinfection
AT gervaixalain procalcitoninakeymarkerinchildrenwithurinarytractinfection