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Mammalian Frataxin: An Essential Function for Cellular Viability through an Interaction with a Preformed ISCU/NFS1/ISD11 Iron-Sulfur Assembly Complex

BACKGROUND: Frataxin, the mitochondrial protein deficient in Friedreich ataxia, a rare autosomal recessive neurodegenerative disorder, is thought to be involved in multiple iron-dependent mitochondrial pathways. In particular, frataxin plays an important role in the formation of iron-sulfur (Fe-S) c...

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Detalles Bibliográficos
Autores principales:	Schmucker, Stéphane, Martelli, Alain, Colin, Florent, Page, Adeline, Wattenhofer-Donzé, Marie, Reutenauer, Laurence, Puccio, Hélène
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027643/ https://www.ncbi.nlm.nih.gov/pubmed/21298097 http://dx.doi.org/10.1371/journal.pone.0016199

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