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Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat
BACKGROUND: The impact of respiratory dynamics on odor response has been poorly studied at the olfactory bulb level. However, it has been shown that sniffing in the behaving rodent is highly dynamic and varies both in frequency and flow rate. Bulbar odor response could vary with these sniffing param...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027679/ https://www.ncbi.nlm.nih.gov/pubmed/21298064 http://dx.doi.org/10.1371/journal.pone.0016445 |
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author | Courtiol, Emmanuelle Amat, Corine Thévenet, Marc Messaoudi, Belkacem Garcia, Samuel Buonviso, Nathalie |
author_facet | Courtiol, Emmanuelle Amat, Corine Thévenet, Marc Messaoudi, Belkacem Garcia, Samuel Buonviso, Nathalie |
author_sort | Courtiol, Emmanuelle |
collection | PubMed |
description | BACKGROUND: The impact of respiratory dynamics on odor response has been poorly studied at the olfactory bulb level. However, it has been shown that sniffing in the behaving rodent is highly dynamic and varies both in frequency and flow rate. Bulbar odor response could vary with these sniffing parameter variations. Consequently, it is necessary to understand how nasal airflow can modify and shape odor response at the olfactory bulb level. METHODOLOGY AND PRINCIPAL FINDINGS: To assess this question, we used a double cannulation and simulated nasal airflow protocol on anesthetized rats to uncouple nasal airflow from animal respiration. Both mitral/tufted cell extracellular unit activity and local field potentials (LFPs) were recorded. We found that airflow changes in the normal range were sufficient to substantially reorganize the response of the olfactory bulb. In particular, cellular odor-evoked activities, LFP oscillations and spike phase-locking to LFPs were strongly modified by nasal flow rate. CONCLUSION: Our results indicate the importance of reconsidering the notion of odor coding as odor response at the bulbar level is ceaselessly modified by respiratory dynamics. |
format | Text |
id | pubmed-3027679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30276792011-02-04 Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat Courtiol, Emmanuelle Amat, Corine Thévenet, Marc Messaoudi, Belkacem Garcia, Samuel Buonviso, Nathalie PLoS One Research Article BACKGROUND: The impact of respiratory dynamics on odor response has been poorly studied at the olfactory bulb level. However, it has been shown that sniffing in the behaving rodent is highly dynamic and varies both in frequency and flow rate. Bulbar odor response could vary with these sniffing parameter variations. Consequently, it is necessary to understand how nasal airflow can modify and shape odor response at the olfactory bulb level. METHODOLOGY AND PRINCIPAL FINDINGS: To assess this question, we used a double cannulation and simulated nasal airflow protocol on anesthetized rats to uncouple nasal airflow from animal respiration. Both mitral/tufted cell extracellular unit activity and local field potentials (LFPs) were recorded. We found that airflow changes in the normal range were sufficient to substantially reorganize the response of the olfactory bulb. In particular, cellular odor-evoked activities, LFP oscillations and spike phase-locking to LFPs were strongly modified by nasal flow rate. CONCLUSION: Our results indicate the importance of reconsidering the notion of odor coding as odor response at the bulbar level is ceaselessly modified by respiratory dynamics. Public Library of Science 2011-01-26 /pmc/articles/PMC3027679/ /pubmed/21298064 http://dx.doi.org/10.1371/journal.pone.0016445 Text en Courtiol et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Courtiol, Emmanuelle Amat, Corine Thévenet, Marc Messaoudi, Belkacem Garcia, Samuel Buonviso, Nathalie Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat |
title | Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat |
title_full | Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat |
title_fullStr | Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat |
title_full_unstemmed | Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat |
title_short | Reshaping of Bulbar Odor Response by Nasal Flow Rate in the Rat |
title_sort | reshaping of bulbar odor response by nasal flow rate in the rat |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3027679/ https://www.ncbi.nlm.nih.gov/pubmed/21298064 http://dx.doi.org/10.1371/journal.pone.0016445 |
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