Combination effects of platinum drugs and N(1), N(11) diethylnorspermine on spermidine/spermine N(1)-acetyltransferase, polyamines and growth inhibition in A2780 human ovarian carcinoma cells and their oxaliplatin and cisplatin-resistant variants

PURPOSE: To understand the mechanisms behind platinum drug/DENSPM-induced inhibition of cancer cell growth, we compared the effects of oxaliplatin and cisplatin when combined with DENSPM on the induction of SSAT mRNA, activity, polyamines and cell growth in A2780 human ovarian carcinoma cells and th...

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Detalles Bibliográficos
Autores principales: Tummala, Ramakumar, Diegelman, Paula, Hector, Suzanne, Kramer, Debora L., Clark, Kimberly, Zagst, Patricia, Fetterly, Gerald, Porter, Carl W., Pendyala, Lakshmi
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028085/
https://www.ncbi.nlm.nih.gov/pubmed/20443003
http://dx.doi.org/10.1007/s00280-010-1334-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028085/
https://www.ncbi.nlm.nih.gov/pubmed/20443003
http://dx.doi.org/10.1007/s00280-010-1334-9

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