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Flow optimization study of a batch microfluidics PET tracer synthesizing device

We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reactio...

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Detalles Bibliográficos
Autores principales: Elizarov, Arkadij M., Meinhart, Carl, Miraghaie, Reza, van Dam, R. Michael, Huang, Jiang, Daridon, Antoine, Heath, James R., Kolb, Hartmuth C.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028087/
https://www.ncbi.nlm.nih.gov/pubmed/21072595
http://dx.doi.org/10.1007/s10544-010-9488-0
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author Elizarov, Arkadij M.
Meinhart, Carl
Miraghaie, Reza
van Dam, R. Michael
Huang, Jiang
Daridon, Antoine
Heath, James R.
Kolb, Hartmuth C.
author_facet Elizarov, Arkadij M.
Meinhart, Carl
Miraghaie, Reza
van Dam, R. Michael
Huang, Jiang
Daridon, Antoine
Heath, James R.
Kolb, Hartmuth C.
author_sort Elizarov, Arkadij M.
collection PubMed
description We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations.
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spelling pubmed-30280872011-02-22 Flow optimization study of a batch microfluidics PET tracer synthesizing device Elizarov, Arkadij M. Meinhart, Carl Miraghaie, Reza van Dam, R. Michael Huang, Jiang Daridon, Antoine Heath, James R. Kolb, Hartmuth C. Biomed Microdevices Article We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations. Springer US 2010-11-12 2011 /pmc/articles/PMC3028087/ /pubmed/21072595 http://dx.doi.org/10.1007/s10544-010-9488-0 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Article
Elizarov, Arkadij M.
Meinhart, Carl
Miraghaie, Reza
van Dam, R. Michael
Huang, Jiang
Daridon, Antoine
Heath, James R.
Kolb, Hartmuth C.
Flow optimization study of a batch microfluidics PET tracer synthesizing device
title Flow optimization study of a batch microfluidics PET tracer synthesizing device
title_full Flow optimization study of a batch microfluidics PET tracer synthesizing device
title_fullStr Flow optimization study of a batch microfluidics PET tracer synthesizing device
title_full_unstemmed Flow optimization study of a batch microfluidics PET tracer synthesizing device
title_short Flow optimization study of a batch microfluidics PET tracer synthesizing device
title_sort flow optimization study of a batch microfluidics pet tracer synthesizing device
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028087/
https://www.ncbi.nlm.nih.gov/pubmed/21072595
http://dx.doi.org/10.1007/s10544-010-9488-0
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