Cargando…

Induction of Mixed Chimerism With MHC-Mismatched but Not Matched Bone Marrow Transplants Results in Thymic Deletion of Host-Type Autoreactive T-Cells in NOD Mice

OBJECTIVE: Induction of mixed or complete chimerism via hematopoietic cell transplantation (HCT) from nonautoimmune donors could prevent or reverse type 1 diabetes (T1D). In clinical settings, HLA-matched HCT is preferred to facilitate engraftment and reduce the risk for graft versus host disease (G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Racine, Jeremy, Wang, Miao, Zhang, Chunyan, Lin, Chia-Lei, Liu, Hongjun, Todorov, Ivan, Atkinson, Mark, Zeng, Defu
Formato:	Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2011
Materias:	Immunology and Transplantation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028355/ https://www.ncbi.nlm.nih.gov/pubmed/21270266 http://dx.doi.org/10.2337/db10-0827

Ejemplares similares

MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice
por: Zhang, Mingfeng, et al.
Publicado: (2018)

Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Diabetes
por: Zhang, Chunyan, et al.
Publicado: (2010)

Complete Diabetes Protection Despite Delayed Thymic Tolerance in NOD8.3 TCR Transgenic Mice Due to Antigen-Induced Extrathymic Deletion of T Cells
por: Krishnamurthy, Balasubramanian, et al.
Publicado: (2012)

Thymic Stromal Lymphopoietin and Thymic Stromal Lymphopoietin–Conditioned Dendritic Cells Induce Regulatory T-Cell Differentiation and Protection of NOD Mice Against Diabetes
por: Besin, Gilles, et al.
Publicado: (2008)

Simultaneous Detection of Circulating Autoreactive CD8(+) T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
por: Velthuis, Jurjen H., et al.
Publicado: (2010)

Transplantation of MHC-mismatched mouse embryonic stem cell-derived thymic epithelial progenitors and MHC-matched bone marrow prevents autoimmune diabetes
por: Su, Min, et al.
Publicado: (2019)

T-replete HLA-matched grafts vs T-depleted HLA-mismatched grafts in inborn errors of immunity
por: Lum, Su Han, et al.
Publicado: (2022)

Inducible Sbds deletion impairs bone marrow niche capacity to engraft donor bone marrow after transplantation
por: Zha, Ji, et al.
Publicado: (2022)

Donor bone marrow–derived macrophage MHC II drives neuroinflammation and altered behavior during chronic GVHD in mice
por: Adams, Rachael C., et al.
Publicado: (2022)

Treg-Specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T-Cell Stability
por: Thirawatananond, Puchong, et al.
Publicado: (2023)

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes
por: Thayer, Terri C., et al.
Publicado: (2011)

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver
por: Preti, Max, et al.
Publicado: (2021)

Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
por: Xue, Song, et al.
Publicado: (2015)

Mesenchymal stromal cells ameliorate chronic GVHD by boosting thymic regeneration in a CCR9-dependent manner in mice
por: Zhang, Xin, et al.
Publicado: (2023)

Ultrasensitive chimerism enhances measurable residual disease testing after allogeneic hematopoietic cell transplantation
por: Kanaan, Sami B., et al.
Publicado: (2023)

A Novel Clinically Relevant Strategy to Abrogate Autoimmunity and Regulate Alloimmunity in NOD Mice
por: Vergani, Andrea, et al.
Publicado: (2010)

Improved GRFS after posttransplant cyclophosphamide-based vs ATG-based HLA-mismatched unrelated donor transplant
por: Jimenez Jimenez, Antonio, et al.
Publicado: (2022)

Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes
por: Mathews, Clayton E., et al.
Publicado: (2015)

B-Lymphocytes Expressing an Ig Specificity Recognizing the Pancreatic β-Cell Autoantigen Peripherin Are Potent Contributors to Type 1 Diabetes Development in NOD Mice
por: Leeth, Caroline M., et al.
Publicado: (2016)

HLA-matching with PTCy: a reanalysis of a CIBMTR dataset with propensity score matching and donor age
por: Ambinder, Alexander, et al.
Publicado: (2022)

Primary graft failure, but not relapse, may be identified by early chimerism following double cord blood unit transplantation
por: Hough, Rachael, et al.
Publicado: (2022)

Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice
por: Sodré, Fernanda M.C., et al.
Publicado: (2021)

The Association Between Broad Antigen HLA Mismatches, Eplet HLA Mismatches and Acute Rejection After Kidney Transplantation
por: Do Nguyen, Hung Thanh, et al.
Publicado: (2016)

IRAK-M Deficiency Promotes the Development of Type 1 Diabetes in NOD Mice
por: Tan, Qiyuan, et al.
Publicado: (2014)

Human β-Cell Killing by Autoreactive Preproinsulin-Specific CD8 T Cells Is Predominantly Granule-Mediated With the Potency Dependent Upon T-Cell Receptor Avidity
por: Knight, Robin R., et al.
Publicado: (2013)

MHC Class II Polymorphisms, Autoreactive T-Cells, and Autoimmunity
por: Tsai, Sue, et al.
Publicado: (2013)

Graft rejection markers in children undergoing hematopoietic cell transplant for bone marrow failure
por: Sabulski, Anthony, et al.
Publicado: (2021)

Abatacept GVHD prophylaxis in unrelated hematopoietic cell transplantation for pediatric bone marrow failure
por: Stenger, Elizabeth O., et al.
Publicado: (2023)

Deletion of the G6pc2 Gene Encoding the Islet-Specific Glucose-6-Phosphatase Catalytic Subunit–Related Protein Does Not Affect the Progression or Incidence of Type 1 Diabetes in NOD/ShiLtJ Mice
por: Oeser, James K., et al.
Publicado: (2011)

Conditioning intensity and probability of live birth after blood or marrow transplantation, a BMTSS report
por: Balas, Nora, et al.
Publicado: (2022)

Cardiac toxicity after matched allogeneic hematopoietic cell transplant in the posttransplant cyclophosphamide era
por: Yeh, Jason, et al.
Publicado: (2021)

Risk of COVID-19 infection in long-term survivors of blood or marrow transplantation: a BMTSS report
por: Johnston, Emily E., et al.
Publicado: (2023)

Donor bone marrow–derived macrophage engraftment into the central nervous system of patients following allogeneic transplantion
por: Loeb, Anisha M., et al.
Publicado: (2023)

Risky health behaviors and subsequent late mortality after blood or marrow transplantation: a BMTSS report
por: Balas, Nora, et al.
Publicado: (2023)

Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice
por: Mangada, Julie, et al.
Publicado: (2009)

IL-13Rα1 Expression on β-Cell–Specific T Cells in NOD Mice
por: Rasche, Sarah S., et al.
Publicado: (2011)

Prevention of Autoimmune Diabetes and Induction of β-Cell Proliferation in NOD Mice by Hyperbaric Oxygen Therapy
por: Faleo, Gaetano, et al.
Publicado: (2012)

Inflammatory Tendencies and Overproduction of IL-17 in the Colon of Young NOD Mice Are Counteracted With Diet Change
por: Alam, Catharina, et al.
Publicado: (2010)

Adoptive Transfer of Immunomodulatory M2 Macrophages Prevents Type 1 Diabetes in NOD Mice
por: Parsa, Roham, et al.
Publicado: (2012)

Impact of allele-level HLA matching on outcomes after double cord blood transplantation in adults with malignancies
por: Fatobene, Giancarlo, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_09ec0b9poj6n9vmjc0e9b51f02