Increased Expression and Activity of 12-Lipoxygenase in Oxygen-Induced Ischemic Retinopathy and Proliferative Diabetic Retinopathy: Implications in Retinal Neovascularization

OBJECTIVE: Arachidonic acid is metabolized by 12-lipoxygenase (12-LOX) to 12-hydroxyeicosatetraenoic acid (12-HETE) and has an important role in the regulation of angiogenesis and endothelial cell proliferation and migration. The goal of this study was to investigate whether 12-LOX plays a role in r...

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Detalles Bibliográficos
Autores principales: Al-Shabrawey, Mohamed, Mussell, Rene, Kahook, Khalid, Tawfik, Amany, Eladl, Mohamed, Sarthy, Vijay, Nussbaum, Julian, El-Marakby, Ahmed, Park, Sun Young, Gurel, Zafer, Sheibani, Nader, Maddipati, Krishna Rao
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Complications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028363/
https://www.ncbi.nlm.nih.gov/pubmed/21228311
http://dx.doi.org/10.2337/db10-0008

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