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Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia
A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjec...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Optical Society of America
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028502/ https://www.ncbi.nlm.nih.gov/pubmed/21326639 http://dx.doi.org/10.1364/BOE.2.000089 |
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author | Schwarz, Richard A. Gao, Wen Stepanek, Vanda M. T. Le, Tao T. Bhattar, Vijayashree S. Williams, Michelle D. Wu, Jessica K. Vigneswaran, Nadarajah Adler-Storthz, Karen Gillenwater, Ann M. Richards-Kortum, Rebecca |
author_facet | Schwarz, Richard A. Gao, Wen Stepanek, Vanda M. T. Le, Tao T. Bhattar, Vijayashree S. Williams, Michelle D. Wu, Jessica K. Vigneswaran, Nadarajah Adler-Storthz, Karen Gillenwater, Ann M. Richards-Kortum, Rebecca |
author_sort | Schwarz, Richard A. |
collection | PubMed |
description | A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83. |
format | Text |
id | pubmed-3028502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Optical Society of America |
record_format | MEDLINE/PubMed |
spelling | pubmed-30285022011-02-16 Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia Schwarz, Richard A. Gao, Wen Stepanek, Vanda M. T. Le, Tao T. Bhattar, Vijayashree S. Williams, Michelle D. Wu, Jessica K. Vigneswaran, Nadarajah Adler-Storthz, Karen Gillenwater, Ann M. Richards-Kortum, Rebecca Biomed Opt Express Optics in Cancer Research A portable, depth-sensitive clinical spectroscopy device for noninvasive early diagnosis of oral cancer is described. We carried out a pilot study to evaluate the ability of the device to identify oral neoplasia using a previously developed diagnostic algorithm. A total of 79 oral sites in 33 subjects, including 28 patients with oral lesions and 5 healthy volunteers, were measured and analyzed. Measurements of 54 nonkeratinized oral sites yielded an area under the receiver operating characteristic curve of 0.90. Measurements of 25 keratinized oral sites yielded an area under the receiver operating characteristic curve of 0.83. Optical Society of America 2010-12-08 /pmc/articles/PMC3028502/ /pubmed/21326639 http://dx.doi.org/10.1364/BOE.2.000089 Text en ©2010 Optical Society of America http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. |
spellingShingle | Optics in Cancer Research Schwarz, Richard A. Gao, Wen Stepanek, Vanda M. T. Le, Tao T. Bhattar, Vijayashree S. Williams, Michelle D. Wu, Jessica K. Vigneswaran, Nadarajah Adler-Storthz, Karen Gillenwater, Ann M. Richards-Kortum, Rebecca Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia |
title | Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia |
title_full | Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia |
title_fullStr | Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia |
title_full_unstemmed | Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia |
title_short | Prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia |
title_sort | prospective evaluation of a portable depth-sensitive optical spectroscopy device to identify oral neoplasia |
topic | Optics in Cancer Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028502/ https://www.ncbi.nlm.nih.gov/pubmed/21326639 http://dx.doi.org/10.1364/BOE.2.000089 |
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