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Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling

AIMS: Pre-eclampsia affects 5–7% of pregnancies, and is a major cause of maternal and foetal death. Elevated serum levels of placentally derived splice variants of the vascular endothelial growth factor (VEGF) receptor, soluble fms-like tyrosine kinase-1 (sFLT1), are strongly implicated in the patho...

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Detalles Bibliográficos
Autores principales:	Cindrova-Davies, Tereza, Sanders, Deborah A., Burton, Graham J., Charnock-Jones, D. Stephen
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2011
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3028975/ https://www.ncbi.nlm.nih.gov/pubmed/21139021 http://dx.doi.org/10.1093/cvr/cvq346

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