Familial CJD Associated PrP Mutants within Transmembrane Region Induced Ctm-PrP Retention in ER and Triggered Apoptosis by ER Stress in SH-SY5Y Cells

BACKGROUND: Genetic prion diseases are linked to point and inserted mutations in the prion protein (PrP) gene that are presumed to favor conversion of the cellular isoform of PrP (PrP(C)) to the pathogenic one (PrP(Sc)). The pathogenic mechanisms and the subcellular sites of the conversion are not c...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Shi, Qi, Xu, Kun, Gao, Chen, Chen, Cao, Li, Xiao-Li, Wang, Gui-Rong, Tian, Chan, Han, Jun, Dong, Xiao-Ping
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029303/
https://www.ncbi.nlm.nih.gov/pubmed/21298055
http://dx.doi.org/10.1371/journal.pone.0014602

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