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Defective Molecular Timer in the Absence of Nucleotides Leads to Inefficient Caspase Activation
In the intrinsic death pathway, cytochrome C (CC) released from mitochondria to the cytosol triggers Apaf-1 apoptosome formation and subsequent caspase activation. This process can be recapitulated using recombinant Apaf-1 and CC in the presence of nucleotides ATP or dATP [(d)ATP] or using fresh cyt...
| Autores principales: | , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029307/ https://www.ncbi.nlm.nih.gov/pubmed/21297999 http://dx.doi.org/10.1371/journal.pone.0016379 |