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Prostaglandin E2 Reverses Aberrant Production of an Inflammatory Chemokine by Microglia from Sandhoff Disease Model Mice through the cAMP-PKA Pathway

BACKGROUND: Sandhoff disease (SD) is a neurodegenerative lysosomal β-hexosaminidase (Hex) deficiency involving excessive accumulation of undegraded substrates, including terminal GlcNAc-oligosaccharides and GM2 ganglioside. Microglia-mediated neuroinflammation contributes to the pathogenesis and pro...

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Detalles Bibliográficos
Autores principales:	Kawashita, Eri, Tsuji, Daisuke, Toyoshima, Masahiro, Kanno, Yosuke, Matsuno, Hiroyuki, Itoh, Kohji
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029311/ https://www.ncbi.nlm.nih.gov/pubmed/21298000 http://dx.doi.org/10.1371/journal.pone.0016269

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