A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses

Development of effective vaccines to prevent influenza, particularly highly pathogenic avian influenza (HPAI) caused by influenza A virus (IAV) subtype H5N1, is a challenging goal. In this study, we designed and constructed two recombinant influenza vaccine candidates by fusing hemagglutinin 1 (HA1)...

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Detalles Bibliográficos
Autores principales: Du, Lanying, Leung, Virtual Ho-Chuen, Zhang, Xiujuan, Zhou, Jie, Chen, Min, He, Wu, Zhang, Hai-Ying, Chan, Chris C. S., Poon, Vincent Kwok-Man, Zhao, Guangyu, Sun, Shihui, Cai, Lifeng, Zhou, Yusen, Zheng, Bo-Jian, Jiang, Shibo
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029370/
https://www.ncbi.nlm.nih.gov/pubmed/21304591
http://dx.doi.org/10.1371/journal.pone.0016555

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