Mucosal Targeting of a BoNT/A Subunit Vaccine Adjuvanted with a Mast Cell Activator Enhances Induction of BoNT/A Neutralizing Antibodies in Rabbits

BACKGROUND: We previously reported that the immunogenicity of Hcβtre, a botulinum neurotoxin A (BoNT/A) immunogen, was enhanced by fusion to an epithelial cell binding domain, Ad2F, when nasally delivered to mice with cholera toxin (CT). This study was performed to determine if Ad2F would enhance th...

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Detalles Bibliográficos
Autores principales: Staats, Herman F., Fielhauer, Jeffrey R., Thompson, Afton L., Tripp, Alice A., Sobel, Ashley E., Maddaloni, Massimo, Abraham, Soman N., Pascual, David W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029387/
https://www.ncbi.nlm.nih.gov/pubmed/21304600
http://dx.doi.org/10.1371/journal.pone.0016532

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