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Molecular Cooperation between the Werner Syndrome Protein and Replication Protein A in Relation to Replication Fork Blockage

The premature aging and cancer-prone disease Werner syndrome is caused by loss of function of the RecQ helicase family member Werner syndrome protein (WRN). At the cellular level, loss of WRN results in replication abnormalities and chromosomal aberrations, indicating that WRN plays a role in mainte...

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Detalles Bibliográficos
Autores principales:	Machwe, Amrita, Lozada, Enerlyn, Wold, Marc S., Li, Guo-Min, Orren, David K.
Formato:	Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2011
Materias:	DNA and Chromosomes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030355/ https://www.ncbi.nlm.nih.gov/pubmed/21107010 http://dx.doi.org/10.1074/jbc.M110.105411

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