Cargando…

mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists

Group II metabotropic glutamate receptors (mGluRs) couple to the inhibitory G-protein Gi. The group II mGluRs include two subtypes, mGlu2 and mGlu3, and their pharmacological activation produces analgesic effects in inflammatory and neuropathic pain states. However, the specific contribution of each...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zammataro, Magda, Chiechio, Santina, Montana, Michael C, Traficante, Anna, Copani, Agata, Nicoletti, Ferdinando, Gereau, Robert W
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Short Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030510/ https://www.ncbi.nlm.nih.gov/pubmed/21235748 http://dx.doi.org/10.1186/1744-8069-7-6

Ejemplares similares

Structural insights into dimerization and activation of the mGlu2–mGlu3 and mGlu2–mGlu4 heterodimers
por: Wang, Xinwei, et al.
Publicado: (2023)

Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice
por: Lane, Tracy A, et al.
Publicado: (2013)

Allosteric Modulators for mGlu Receptors
por: Gasparini, F, et al.
Publicado: (2007)

Place field stability requires the metabotropic glutamate receptor, mGlu5
por: Zhang, Sijie, et al.
Publicado: (2014)

mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors
por: Notartomaso, Serena, et al.
Publicado: (2018)

An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety
por: Ramos-Prats, Arnau, et al.
Publicado: (2019)

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light
por: Pritchett, David, et al.
Publicado: (2015)

A group II metabotropic glutamate receptor 3 (mGlu3, GRM3) isoform implicated in schizophrenia interacts with canonical mGlu3 and reduces ligand binding
por: García-Bea, Aintzane, et al.
Publicado: (2017)

Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons
por: Mao, Li-Min, et al.
Publicado: (2022)

mGlu5 Receptor Functional Interactions and Addiction
por: Brown, Robyn M., et al.
Publicado: (2012)

Targeting mGlu5 Metabotropic Glutamate Receptors in the Treatment of Cognitive Dysfunction in a Mouse Model of Phenylketonuria
por: Nardecchia, Francesca, et al.
Publicado: (2018)

Genetic deletion of mGlu2 metabotropic glutamate receptors improves the short-term outcome of cerebral transient focal ischemia
por: Mastroiacovo, Federica, et al.
Publicado: (2017)

Emotional Impairment and Persistent Upregulation of mGlu(5) Receptor following Morphine Abstinence: Implications of an mGlu(5)-MOPr Interaction
por: Zanos, Panos, et al.
Publicado: (2016)

Targeting mGlu Receptors for Optimization of Antipsychotic Activity and Disease-Modifying Effect in Schizophrenia
por: Nicoletti, Ferdinando, et al.
Publicado: (2019)

Genetic Deletion of mGlu3 Metabotropic Glutamate Receptors Amplifies Ischemic Brain Damage and Associated Neuroinflammation in Mice
por: Mastroiacovo, Federica, et al.
Publicado: (2021)

Tetrahydronaphthyridine and Dihydronaphthyridinone Ethers As Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 5 (mGlu(5))
por: Turlington, Mark, et al.
Publicado: (2014)

Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7
por: Bushell, Trevor J., et al.
Publicado: (2002)

Protein Networks Associated with Native Metabotropic Glutamate 1 Receptors (mGlu(1)) in the Mouse Cerebellum
por: Mansouri, Mahnaz, et al.
Publicado: (2023)

mGlu3 Metabotropic Glutamate Receptors as a Target for the Treatment of Absence Epilepsy: Preclinical and Human Genetics Data
por: Celli, Roberta, et al.
Publicado: (2023)

Neurobiological Insights from mGlu Receptor Allosteric Modulation
por: O’Brien, Daniel E, et al.
Publicado: (2015)

mGlu3 receptor regulates microglial cell reactivity in neonatal rats
por: Zinni, Manuela, et al.
Publicado: (2021)

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia
por: Fazio, Francesco, et al.
Publicado: (2015)

Activation of mGlu3 Receptors Stimulates the Production of GDNF in Striatal Neurons
por: Battaglia, Giuseppe, et al.
Publicado: (2009)

Chronic Treatment with Fluoxetine Induces Sex-Dependent Analgesic Effects and Modulates HDAC2 and mGlu2 Expression in Female Mice
por: Zammataro, Magda, et al.
Publicado: (2017)

The Metabotropic Glutamate Receptor, mGlu5, Is Required for Extinction Learning That Occurs in the Absence of a Context Change
por: André, Marion Agnes Emma, et al.
Publicado: (2015)

Glutamate Metabotropic Receptor Type 3 (mGlu3) Localization in the Rat Prelimbic Medial Prefrontal Cortex
por: Woo, Elizabeth, et al.
Publicado: (2022)

Fractionation of Spatial Memory in GRM2/3 (mGlu2/mGlu3) Double Knockout Mice Reveals a Role for Group II Metabotropic Glutamate Receptors at the Interface Between Arousal and Cognition
por: Lyon, Louisa, et al.
Publicado: (2011)

mGlu(5) Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu(5)-Endocannabinoid Signaling
por: Xiang, Zixiu, et al.
Publicado: (2019)

Preclinical and translational studies of fenobam, an mGlu5 NAM, for the treatment of pain
por: Gereau IV, Robert W, et al.
Publicado: (2014)

Function of mGlu1 receptors in the modulation of nociceptive processing in the thalamus()
por: Salt, T.E., et al.
Publicado: (2014)

The role of thalamic group II mGlu receptors in health and disease
por: Copeland, Caroline S., et al.
Publicado: (2022)

Exploring the Activation Mechanism of the mGlu5 Transmembrane Domain
por: Lans, Isaias, et al.
Publicado: (2020)

Regulation and functional consequences of mGlu(4) RNA editing
por: Hofmann, Christopher S., et al.
Publicado: (2021)

Differential activity of mGlu(7) allosteric modulators provides evidence for mGlu(7/8) heterodimers at hippocampal Schaffer collateral-CA1 synapses
por: Lin, Xin, et al.
Publicado: (2022)

Role of the G Protein-Coupled Receptor, mGlu(1), in Melanoma Development
por: Wangari-Talbot, Janet, et al.
Publicado: (2010)

Phasic and Tonic mGlu7 Receptor Activity Modulates the Thalamocortical Network
por: Tassin, Valériane, et al.
Publicado: (2016)

Presynaptic Release-Regulating mGlu1 Receptors in Central Nervous System
por: Pittaluga, Anna
Publicado: (2016)

Negative Allosteric Modulators of mGlu(7) Receptor as Putative Antipsychotic Drugs
por: Cieślik, Paulina, et al.
Publicado: (2018)

Changes in mGlu5 Receptor Signaling Are Associated with Associative Learning and Memory Extinction in Mice
por: Teleuca, Ana Elena, et al.
Publicado: (2022)

Could MDMA Promote Stemness Characteristics in Mouse Embryonic Stem Cells via mGlu5 Metabotropic Glutamate Receptors?
por: Meamar, Rokhsareh, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_pblr4sci0dts9cnedt7ooseqp7