Cargando…

Characterizing Ligand-Gated Ion Channel Receptors with Genetically Encoded Ca(++) Sensors

We present a cell based system and experimental approach to characterize agonist and antagonist selectivity for ligand-gated ion channels (LGIC) by developing sensor cells stably expressing a Ca(2+) permeable LGIC and a genetically encoded Förster (or fluorescence) resonance energy transfer (FRET)-b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yamauchi, John G., Nemecz, Ákos, Nguyen, Quoc Thang, Muller, Arnaud, Schroeder, Lee F., Talley, Todd T., Lindstrom, Jon, Kleinfeld, David, Taylor, Palmer
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030600/ https://www.ncbi.nlm.nih.gov/pubmed/21305050 http://dx.doi.org/10.1371/journal.pone.0016519

Ejemplares similares

Full mutational mapping of titratable residues helps to identify proton-sensors involved in the control of channel gating in the Gloeobacter violaceus pentameric ligand-gated ion channel
por: Nemecz, Ákos, et al.
Publicado: (2017)

Interplay between Gating and Block of Ligand-Gated Ion Channels
por: Phillips, Matthew B., et al.
Publicado: (2020)

Allosteric coupling in ligand-gated ion channels
por: Colquhoun, David, et al.
Publicado: (2012)

Effects of cannabinoids on ligand-gated ion channels
por: Oz, Murat, et al.
Publicado: (2022)

The Role of Ion Channels in Microglial Activation and Proliferation – A Complex Interplay between Ligand-Gated Ion Channels, K(+) Channels, and Intracellular Ca(2+)
por: Stebbing, Martin James, et al.
Publicado: (2015)

Fast functional mapping of ligand-gated ion channels
por: Schmauder, Ralf, et al.
Publicado: (2023)

Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
por: Zimmermann, Iwan, et al.
Publicado: (2011)

An in vivo biosensor for neurotransmitter release and in situ receptor activity
por: Nguyen, Quoc-Thang, et al.
Publicado: (2009)

Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions
por: Rao, Shanlin, et al.
Publicado: (2021)

Extracellular protons titrate voltage gating of a ligand-gated ion channel
por: Martínez-François, Juan Ramón, et al.
Publicado: (2010)

About a new method to measure fractional Ca(2+) currents through ligand-gated ion channels
por: Fucile, Sergio, et al.
Publicado: (2009)

Phylogenomics of Ligand-Gated Ion Channels Predicts Monepantel Effect
por: Rufener, Lucien, et al.
Publicado: (2010)

Ligand-gated ion channel interacting proteins and their role in neuroprotection
por: Li, Shupeng, et al.
Publicado: (2014)

Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels
por: Mowrey, David, et al.
Publicado: (2013)

Amphetamine activates/potentiates a ligand-gated ion channel
por: Carvelli, Lucia
Publicado: (2014)

Ligand-Gated Ion Channels as Targets for Treatment and Management of Cancers
por: Rao, Rohan, et al.
Publicado: (2022)

Derepression may masquerade as activation in ligand-gated ion channels
por: Tessier, Christian J. G., et al.
Publicado: (2023)

Ligand-Gated Ion Channels: Prognostic and Therapeutic Implications for Gliomas
por: Hey, Grace, et al.
Publicado: (2023)

Functional Modifications of Acid-Sensing Ion Channels by Ligand-Gated Chloride Channels
por: Chen, Xuanmao, et al.
Publicado: (2011)

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels
por: Sauguet, Ludovic, et al.
Publicado: (2013)

Probing function in ligand-gated ion channels without measuring ion transport
por: Godellas, Nicole E., et al.
Publicado: (2022)

Molecular Mingling: Multimodal Predictions of Ligand Promiscuity in Pentameric Ligand-Gated Ion Channels
por: Koniuszewski, Filip, et al.
Publicado: (2022)

Neuronally produced betaine acts via a ligand-gated ion channel to control behavioral states
por: Hardege, Iris, et al.
Publicado: (2022)

Site-Directed Spin Labeling Reveals Pentameric Ligand-Gated Ion Channel Gating Motions
por: Dellisanti, Cosma D., et al.
Publicado: (2013)

From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules
por: Nasiripourdori, Adak, et al.
Publicado: (2011)

The Concise Guide to Pharmacology 2013/14: Ligand-Gated Ion Channels
por: Alexander, Stephen PH, et al.
Publicado: (2013)

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop Receptors
por: Jaiteh, Mariama, et al.
Publicado: (2016)

The Concise Guide to PHARMACOLOGY 2015/16: Ligand‐gated ion channels
por: Alexander, Stephen PH, et al.
Publicado: (2015)

Fatty Acid Regulation of Voltage- and Ligand-Gated Ion Channel Function
por: Antollini, Silvia S., et al.
Publicado: (2016)

Chasing the open-state structure of pentameric ligand-gated ion channels
por: Gonzalez-Gutierrez, Giovanni, et al.
Publicado: (2017)

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand‐gated ion channels
por: Alexander, Stephen PH, et al.
Publicado: (2017)

Drosophila ppk19 encodes a proton-gated and mechanosensitive ion channel
por: Jang, Wijeong, et al.
Publicado: (2022)

Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels
por: Tasneem, Asba, et al.
Publicado: (2005)

Response to the Letter: “About a new method to measure fractional Ca(2+) currents through ligand-gated ion channels”
por: Elenes, Sergio, et al.
Publicado: (2009)

Un-gating and allosteric modulation of a pentameric ligand-gated ion channel captured by molecular dynamics
por: Martin, Nicolas E, et al.
Publicado: (2017)

Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations
por: Zimmermann, Iwan, et al.
Publicado: (2012)

Allosteric regulation of pentameric ligand-gated ion channels: An emerging mechanistic perspective
por: Taly, Antoine, et al.
Publicado: (2014)

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels
por: Bertozzi, Carlo, et al.
Publicado: (2016)

Pentameric Ligand-Gated Ion Channels as Pharmacological Targets Against Chronic Pain
por: Lara, César O., et al.
Publicado: (2020)

The surprising difficulty of “simple” equilibrium binding measurements on ligand-gated ion channels
por: Middendorf, Thomas R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kkhk4hr46rrmrt90mmmbe9rvm3