In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis

Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is usually treated with metronidazole, however resistance is on the rise. In this study, N-chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use, killed T. vaginalis in vitro within 15 min of treatment at a...

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Detalles Bibliográficos
Autores principales: Fürnkranz, Ursula, Nagl, Markus, Gottardi, Waldemar, Duchêne, Michael, Aspöck, Horst, Walochnik, Julia
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030749/
https://www.ncbi.nlm.nih.gov/pubmed/21074373
http://dx.doi.org/10.1016/j.ijantimicag.2010.09.006
Descripción
Sumario:Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is usually treated with metronidazole, however resistance is on the rise. In this study, N-chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use, killed T. vaginalis in vitro within 15 min of treatment at a concentration of 55 mM (1%), which is well tolerated by human tissue. The activity of NCT was further enhanced by addition of ammonium chloride (NH(4)Cl). A combination of 5.5 mM (0.1%) NCT plus 19 mM (0.1%) NH(4)Cl killed 100% of trichomonads within 5 min.

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