In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis

Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is usually treated with metronidazole, however resistance is on the rise. In this study, N-chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use, killed T. vaginalis in vitro within 15 min of treatment at a...

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Detalles Bibliográficos
Autores principales: Fürnkranz, Ursula, Nagl, Markus, Gottardi, Waldemar, Duchêne, Michael, Aspöck, Horst, Walochnik, Julia
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Publishers 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030749/
https://www.ncbi.nlm.nih.gov/pubmed/21074373
http://dx.doi.org/10.1016/j.ijantimicag.2010.09.006
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author Fürnkranz, Ursula
Nagl, Markus
Gottardi, Waldemar
Duchêne, Michael
Aspöck, Horst
Walochnik, Julia
author_facet Fürnkranz, Ursula
Nagl, Markus
Gottardi, Waldemar
Duchêne, Michael
Aspöck, Horst
Walochnik, Julia
author_sort Fürnkranz, Ursula
collection PubMed
description Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is usually treated with metronidazole, however resistance is on the rise. In this study, N-chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use, killed T. vaginalis in vitro within 15 min of treatment at a concentration of 55 mM (1%), which is well tolerated by human tissue. The activity of NCT was further enhanced by addition of ammonium chloride (NH(4)Cl). A combination of 5.5 mM (0.1%) NCT plus 19 mM (0.1%) NH(4)Cl killed 100% of trichomonads within 5 min.
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spelling pubmed-30307492011-02-10 In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis Fürnkranz, Ursula Nagl, Markus Gottardi, Waldemar Duchêne, Michael Aspöck, Horst Walochnik, Julia Int J Antimicrob Agents Short Communication Trichomoniasis, caused by the protozoan Trichomonas vaginalis, is usually treated with metronidazole, however resistance is on the rise. In this study, N-chlorotaurine (NCT), a new endogenous mild active chlorine compound for topical use, killed T. vaginalis in vitro within 15 min of treatment at a concentration of 55 mM (1%), which is well tolerated by human tissue. The activity of NCT was further enhanced by addition of ammonium chloride (NH(4)Cl). A combination of 5.5 mM (0.1%) NCT plus 19 mM (0.1%) NH(4)Cl killed 100% of trichomonads within 5 min. Elsevier Science Publishers 2011-02 /pmc/articles/PMC3030749/ /pubmed/21074373 http://dx.doi.org/10.1016/j.ijantimicag.2010.09.006 Text en © 2011 Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/3.0/ Open Access under CC BY-NC-ND 3.0 (https://creativecommons.org/licenses/by-nc-nd/3.0/) license
spellingShingle Short Communication
Fürnkranz, Ursula
Nagl, Markus
Gottardi, Waldemar
Duchêne, Michael
Aspöck, Horst
Walochnik, Julia
In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis
title In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis
title_full In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis
title_fullStr In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis
title_full_unstemmed In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis
title_short In vitro activity of N-chlorotaurine (NCT) in combination with NH(4)Cl against Trichomonas vaginalis
title_sort in vitro activity of n-chlorotaurine (nct) in combination with nh(4)cl against trichomonas vaginalis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030749/
https://www.ncbi.nlm.nih.gov/pubmed/21074373
http://dx.doi.org/10.1016/j.ijantimicag.2010.09.006
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