Main results of the Ouabain and Adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

BACKGROUND: The Ouabain and Adducin for Specific Intervention on Sodium in Hypertension (OASIS-HT) Trial was a phase-2 dose-finding study of rostafuroxin, a digitoxygenin derivative, which selectively antagonizes the effects of endogenous ouabain (EO) on Na(+),K(+)-ATPase and mutated adducin. Rostaf...

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Detalles Bibliográficos
Autores principales: Staessen, Jan A, Thijs, Lutgarde, Stolarz-Skrzypek, Katarzyna, Bacchieri, Antonella, Barton, John, Espositi, Ezio degli, de Leeuw, Peter W, Dłużniewski, Mirosław, Glorioso, Nicola, Januszewicz, Andrzej, Manunta, Paolo, Milyagin, Viktor, Nikitin, Yuri, Souček, Miroslav, Lanzani, Chiara, Citterio, Lorena, Timio, Mario, Tykarski, Andrzej, Ferrari, Patrizia, Valentini, Giovanni, Kawecka-Jaszcz, Kalina, Bianchi, Giuseppe
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031200/
https://www.ncbi.nlm.nih.gov/pubmed/21235787
http://dx.doi.org/10.1186/1745-6215-12-13

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