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Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain?
Mycobacterium avium, subspecies paratuberculosis (MAP) causes a chronic disease of the intestines in dairy cows and a wide range of other animals, including nonhuman primates, called Johne's ("Yo-knee's") disease. MAP has been consistently identified by a variety of techniques in...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031217/ https://www.ncbi.nlm.nih.gov/pubmed/21167058 http://dx.doi.org/10.1186/1757-4749-2-21 |
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author | Pierce, Ellen S |
author_facet | Pierce, Ellen S |
author_sort | Pierce, Ellen S |
collection | PubMed |
description | Mycobacterium avium, subspecies paratuberculosis (MAP) causes a chronic disease of the intestines in dairy cows and a wide range of other animals, including nonhuman primates, called Johne's ("Yo-knee's") disease. MAP has been consistently identified by a variety of techniques in humans with Crohn's disease. The research investigating the presence of MAP in patients with Crohn's disease has often identified MAP in the "negative" ulcerative colitis controls as well, suggesting that ulcerative colitis is also caused by MAP. Like other infectious diseases, dose, route of infection, age, sex and genes influence whether an individual infected with MAP develops ulcerative colitis or Crohn's disease. The apparently opposite role of smoking, increasing the risk of Crohn's disease while decreasing the risk of ulcerative colitis, is explained by a more careful review of the literature that reveals smoking causes an increase in both diseases but switches the phenotype from ulcerative colitis to Crohn's disease. MAP as the sole etiologic agent of both ulcerative colitis and Crohn's disease explains their common epidemiology, geographic distribution and familial and sporadic clusters, providing a unified hypothesis for the prevention and cure of the no longer "idiopathic" inflammatory bowel diseases. |
format | Text |
id | pubmed-3031217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-30312172011-02-01 Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? Pierce, Ellen S Gut Pathog Commentary Mycobacterium avium, subspecies paratuberculosis (MAP) causes a chronic disease of the intestines in dairy cows and a wide range of other animals, including nonhuman primates, called Johne's ("Yo-knee's") disease. MAP has been consistently identified by a variety of techniques in humans with Crohn's disease. The research investigating the presence of MAP in patients with Crohn's disease has often identified MAP in the "negative" ulcerative colitis controls as well, suggesting that ulcerative colitis is also caused by MAP. Like other infectious diseases, dose, route of infection, age, sex and genes influence whether an individual infected with MAP develops ulcerative colitis or Crohn's disease. The apparently opposite role of smoking, increasing the risk of Crohn's disease while decreasing the risk of ulcerative colitis, is explained by a more careful review of the literature that reveals smoking causes an increase in both diseases but switches the phenotype from ulcerative colitis to Crohn's disease. MAP as the sole etiologic agent of both ulcerative colitis and Crohn's disease explains their common epidemiology, geographic distribution and familial and sporadic clusters, providing a unified hypothesis for the prevention and cure of the no longer "idiopathic" inflammatory bowel diseases. BioMed Central 2010-12-17 /pmc/articles/PMC3031217/ /pubmed/21167058 http://dx.doi.org/10.1186/1757-4749-2-21 Text en Copyright ©2010 Pierce; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Pierce, Ellen S Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? |
title | Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? |
title_full | Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? |
title_fullStr | Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? |
title_full_unstemmed | Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? |
title_short | Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain? |
title_sort | ulcerative colitis and crohn's disease: is mycobacterium avium subspecies paratuberculosis the common villain? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031217/ https://www.ncbi.nlm.nih.gov/pubmed/21167058 http://dx.doi.org/10.1186/1757-4749-2-21 |
work_keys_str_mv | AT pierceellens ulcerativecolitisandcrohnsdiseaseismycobacteriumaviumsubspeciesparatuberculosisthecommonvillain |