Cargando…

Simvastatin reduces atherogenesis and promotes the expression of hepatic genes associated with reverse cholesterol transport in apoE-knockout mice fed high-fat diet

BACKGROUND: Statins are first-line pharmacotherapeutic agents for hypercholesterolemia treatment in humans. However the effects of statins on atherosclerosis in mouse models are very paradoxical. In this work, we wanted to evaluate the effects of simvastatin on serum cholesterol, atherogenesis, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Guohua, Liu, Jia, Zhao, Zhenmei, Yu, Yang, Tian, Hua, Yao, Shutong, Li, Guoli, Qin, Shucun
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031258/ https://www.ncbi.nlm.nih.gov/pubmed/21241519 http://dx.doi.org/10.1186/1476-511X-10-8

Ejemplares similares

Quercetin improves macrophage reverse cholesterol transport in apolipoprotein E-deficient mice fed a high-fat diet
por: Cui, Yingjie, et al.
Publicado: (2017)

Inhibitory effect of the combination therapy of simvastatin and pinocembrin on atherosclerosis in apoE-deficient mice
por: Sang, Hui, et al.
Publicado: (2012)

Genetic and Epigenetic Regulation of Lipoxygenase Pathways and Reverse Cholesterol Transport in Atherogenesis
por: Kotlyarov, Stanislav
Publicado: (2022)

Ethanolic extract of propolis inhibits atherosclerosis in ApoE-knockout mice
por: Fang, Yongqi, et al.
Publicado: (2013)

Cigarette smoke exposure impairs reverse cholesterol transport which can be minimized by treatment of hydrogen-saturated saline
por: Zong, Chuanlong, et al.
Publicado: (2015)

Cholesterol Transport Dysfunction and Its Involvement in Atherogenesis
por: Poznyak, Anastasia V., et al.
Publicado: (2022)

Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR(−/−) mice fed on high-fat diet
por: Liu, Lin, et al.
Publicado: (2019)

Ezetimibe and Simvastatin Reduce Cholesterol Levels in Zebrafish Larvae Fed a High-Cholesterol Diet
por: Baek, Ji Sun, et al.
Publicado: (2012)

Chronopharmacology of simvastatin on hyperlipidaemia in high‐fat diet‐fed obese mice
por: Li, Huan, et al.
Publicado: (2020)

Omega 3 Fatty Acids Promote Macrophage Reverse Cholesterol Transport in Hamster Fed High Fat Diet
por: Kasbi Chadli, Fatima, et al.
Publicado: (2013)

Author Correction: Surgical fat removal exacerbates metabolic disorders but not atherogenesis in LDLR(−/−) mice fed on high-fat diet
por: Liu, Lin, et al.
Publicado: (2020)

Atorvastatin attenuates p-cresyl sulfate-induced atherogenesis and plaque instability in ApoE knockout mice
por: Han, Hui, et al.
Publicado: (2016)

Antioxidation Effect of Simvastatin in Aorta and Hippocampus: A Rabbit Model Fed High-Cholesterol Diet
por: Zhang, Guangyin, et al.
Publicado: (2016)

Nur77 Decreases Atherosclerosis Progression in apoE(−/−) Mice Fed a High-Fat/High-Cholesterol Diet
por: Hu, Yan-Wei, et al.
Publicado: (2014)

VNN1 promotes atherosclerosis progression in apoE(−/−) mice fed a high-fat/high-cholesterol diet
por: Hu, Yan-Wei, et al.
Publicado: (2016)

Methotrexate in Atherogenesis and Cholesterol Metabolism
por: Coomes, Eric, et al.
Publicado: (2011)

Thalidomide influences atherogenesis in aortas of ApoE(−/−)/LDLR(−/−) double knockout mice: a nano-CT study
por: Kampschulte, Marian, et al.
Publicado: (2014)

The combination of L-4F and simvastatin stimulate cholesterol efflux and related proteins expressions to reduce atherosclerotic lesions in apoE knockout mice
por: Ying, Ru, et al.
Publicado: (2013)

Rosiglitazone modulates collagen deposition and metabolism in atherosclerotic plaques of fat-fed ApoE-knockout mice
por: ZHOU, MINGXUE, et al.
Publicado: (2015)

Effects of Six Weeks of Hypoxia Exposure on Hepatic Fatty Acid Metabolism in ApoE Knockout Mice Fed a High-Fat Diet
por: Wang, Yangwenjie, et al.
Publicado: (2022)

Western Diet-Fed ApoE Knockout Male Mice as an Experimental Model of Non-Alcoholic Steatohepatitis
por: Camargo, Felipe N., et al.
Publicado: (2022)

Canagliflozin Attenuates Hepatic Steatosis and Atherosclerosis Progression in Western Diet-Fed ApoE-Knockout Mice
por: Zuo, Qingjuan, et al.
Publicado: (2022)

Rosmarinic Acid Exhibits a Lipid-Lowering Effect by Modulating the Expression of Reverse Cholesterol Transporters and Lipid Metabolism in High-Fat Diet-Fed Mice
por: Nyandwi, Jean Baptiste, et al.
Publicado: (2021)

Atherogenesis in Apoe(−/−) and Ldlr(−/−) Mice with a Genetically Resistant Background
por: Torikai, Hideyuki, et al.
Publicado: (2023)

BSN723T Prevents Atherosclerosis and Weight Gain in ApoE Knockout Mice Fed a Western Diet
por: Williams, Jarrod, et al.
Publicado: (2015)

Kefir peptides attenuate atherosclerotic vascular calcification and osteoporosis in atherogenic diet-fed ApoE (−/−) knockout mice
por: Chang, Gary Ro-Lin, et al.
Publicado: (2023)

Cholesterol in the Cell Membrane—An Emerging Player in Atherogenesis
por: Paukner, Karel, et al.
Publicado: (2022)

A Western-Fed Diet Increases Plasma HDL and LDL-Cholesterol Levels in ApoD–/– Mice
por: Ali, Kamilah, et al.
Publicado: (2014)

Aerobic Exercise Training Reduces Atherogenesis Induced by Low-Sodium Diet in LDL Receptor Knockout Mice
por: Bochi, Ana Paula Garcia, et al.
Publicado: (2022)

Hypocholesterolemic effect of β-caryophyllene in rats fed cholesterol and fat enriched diet
por: Harb, Amani A., et al.
Publicado: (2018)

NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance
por: Li, Shengbing, et al.
Publicado: (2016)

Ginkgolide B Reduces Atherogenesis and Vascular Inflammation in ApoE(−/−) Mice
por: Liu, Xiyun, et al.
Publicado: (2012)

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE(-/-) mice
por: Jehle, Julian, et al.
Publicado: (2018)

Effect of testosterone deficiency on cholesterol metabolism in pigs fed a high-fat and high-cholesterol diet
por: Cai, Zhaowei, et al.
Publicado: (2015)

Monobutyrin and Monovalerin Affect Brain Short-Chain Fatty Acid Profiles and Tight-Junction Protein Expression in ApoE-Knockout Rats Fed High-Fat Diets
por: Nguyen, Thao Duy, et al.
Publicado: (2020)

Activation of 5-HT(2) Receptors Reduces Inflammation in Vascular Tissue and Cholesterol Levels in High-Fat Diet-Fed Apolipoprotein E Knockout Mice
por: Flanagan, Thomas W., et al.
Publicado: (2019)

Impact of chronic methamphetamine treatment on the atherosclerosis formation in ApoE−/− mice fed a high cholesterol diet
por: Zhu, Pengfei, et al.
Publicado: (2017)

Isochlorogenic Acid C Alleviates High-Fat Diet-Induced Hyperlipemia by Promoting Cholesterol Reverse Transport
por: Zheng, Liuyi, et al.
Publicado: (2022)

Infliximab Reverses Suppression of Cholesterol Efflux Proteins by TNF-α: A Possible Mechanism for Modulation of Atherogenesis
por: Voloshyna, Iryna, et al.
Publicado: (2014)

The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice
por: Janssen, Carola I. F., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pc6tokun9feffqlpkalp04krel