The endoplasmic reticulum–associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3–dependent degradation of nascent CFTRΔF508

Relative contributions of folding kinetics versus protein quality control (QC) activity in the partitioning of non-native proteins between life and death are not clear. Cystic fibrosis transmembrane conductance regulator (CFTR) biogenesis serves as an excellent model to study this question because f...

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Detalles Bibliográficos
Autores principales: Grove, Diane E., Fan, Chun-Yang, Ren, Hong Yu, Cyr, Douglas M.
Formato: Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2011
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031462/
https://www.ncbi.nlm.nih.gov/pubmed/21148293
http://dx.doi.org/10.1091/mbc.E10-09-0760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031462/
https://www.ncbi.nlm.nih.gov/pubmed/21148293
http://dx.doi.org/10.1091/mbc.E10-09-0760

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