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Apolipoprotein E: Isoform Specific Differences in Tertiary Structure and Interaction with Amyloid-β in Human Alzheimer Brain

We applied a novel application of FLIM-FRET to in situ measurement and quantification of protein interactions to explore isoform specific differences in Aβ-ApoE interaction and ApoE tertiary conformation in senile plaques in human Alzheimer brain. ApoE3 interacts more closely with Aβ than ApoE4, but...

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Detalles Bibliográficos
Autores principales:	Jones, Phillip B., Adams, Kenneth W., Rozkalne, Anete, Spires-Jones, Tara L., Hshieh, Tammy T., Hashimoto, Tadafumi, von Armin, Christine A. F., Mielke, Mathew, Bacskai, Brian J., Hyman, Bradley T.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031506/ https://www.ncbi.nlm.nih.gov/pubmed/21297948 http://dx.doi.org/10.1371/journal.pone.0014586

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