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Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands

Ticks that feed on vertebrate hosts use their salivary secretion, which contains various bioactive components, to manipulate the host's responses. The mechanisms controlling the tick salivary gland in this dynamic process are not well understood. We identified the tick D1 receptor activated by...

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Detalles Bibliográficos
Autores principales: Šimo, Ladislav, Koči, Juraj, Žitňan, Dušan, Park, Yoonseong
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031531/
https://www.ncbi.nlm.nih.gov/pubmed/21297964
http://dx.doi.org/10.1371/journal.pone.0016158
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author Šimo, Ladislav
Koči, Juraj
Žitňan, Dušan
Park, Yoonseong
author_facet Šimo, Ladislav
Koči, Juraj
Žitňan, Dušan
Park, Yoonseong
author_sort Šimo, Ladislav
collection PubMed
description Ticks that feed on vertebrate hosts use their salivary secretion, which contains various bioactive components, to manipulate the host's responses. The mechanisms controlling the tick salivary gland in this dynamic process are not well understood. We identified the tick D1 receptor activated by dopamine, a potent inducer of the salivary secretion of ticks. Temporal and spatial expression patterns examined by immunohistochemistry and reverse transcription polymerase chain reaction suggest that the dopamine produced in the basal cells of salivary gland acini is secreted into the lumen and activates the D1 receptors on the luminal surface of the cells lining the acini. Therefore, we propose a paracrine function of dopamine that is mediated by the D1 receptor in the salivary gland at an early phase of feeding. The molecular and pharmacological characterization of the D1 receptor in this study provides the foundation for understanding the functions of dopamine in the blood-feeding of ticks.
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spelling pubmed-30315312011-02-04 Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands Šimo, Ladislav Koči, Juraj Žitňan, Dušan Park, Yoonseong PLoS One Research Article Ticks that feed on vertebrate hosts use their salivary secretion, which contains various bioactive components, to manipulate the host's responses. The mechanisms controlling the tick salivary gland in this dynamic process are not well understood. We identified the tick D1 receptor activated by dopamine, a potent inducer of the salivary secretion of ticks. Temporal and spatial expression patterns examined by immunohistochemistry and reverse transcription polymerase chain reaction suggest that the dopamine produced in the basal cells of salivary gland acini is secreted into the lumen and activates the D1 receptors on the luminal surface of the cells lining the acini. Therefore, we propose a paracrine function of dopamine that is mediated by the D1 receptor in the salivary gland at an early phase of feeding. The molecular and pharmacological characterization of the D1 receptor in this study provides the foundation for understanding the functions of dopamine in the blood-feeding of ticks. Public Library of Science 2011-01-31 /pmc/articles/PMC3031531/ /pubmed/21297964 http://dx.doi.org/10.1371/journal.pone.0016158 Text en Šimo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Šimo, Ladislav
Koči, Juraj
Žitňan, Dušan
Park, Yoonseong
Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands
title Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands
title_full Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands
title_fullStr Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands
title_full_unstemmed Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands
title_short Evidence for D1 Dopamine Receptor Activation by a Paracrine Signal of Dopamine in Tick Salivary Glands
title_sort evidence for d1 dopamine receptor activation by a paracrine signal of dopamine in tick salivary glands
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031531/
https://www.ncbi.nlm.nih.gov/pubmed/21297964
http://dx.doi.org/10.1371/journal.pone.0016158
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