Loss of Guanylyl Cyclase C (GCC) Signaling Leads to Dysfunctional Intestinal Barrier

BACKGROUND: Guanylyl Cyclase C (GCC) signaling via uroguanylin (UGN) and guanylin activation is a critical mediator of intestinal fluid homeostasis, intestinal cell proliferation/apoptosis, and tumorigenesis. As a mechanism for some of these effects, we hypothesized that GCC signaling mediates regul...

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Detalles Bibliográficos
Autores principales: Han, Xiaonan, Mann, Elizabeth, Gilbert, Shila, Guan, Yanfang, Steinbrecher, Kris A., Montrose, Marshall H., Cohen, Mitchell B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031533/
https://www.ncbi.nlm.nih.gov/pubmed/21305056
http://dx.doi.org/10.1371/journal.pone.0016139

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