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Humanization and Characterization of an Anti-Human TNF-α Murine Monoclonal Antibody
A murine monoclonal antibody, m357, showing the highly neutralizing activities for human tumor necrosis factor (TNF-α) was chosen to be humanized by a variable domain resurfacing approach. The non-conserved surface residues in the framework regions of both the heavy and light chain variable regions...
| Autores principales: | , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031550/ https://www.ncbi.nlm.nih.gov/pubmed/21305012 http://dx.doi.org/10.1371/journal.pone.0016373 |