MicroRNAs Differentially Expressed in Postnatal Aortic Development Downregulate Elastin via 3′ UTR and Coding-Sequence Binding Sites

Elastin production is characteristically turned off during the maturation of elastin-rich organs such as the aorta. MicroRNAs (miRNAs) are small regulatory RNAs that down-regulate target mRNAs by binding to miRNA regulatory elements (MREs) typically located in the 3′ UTR. Here we show a striking up-...

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Detalles Bibliográficos
Autores principales: Ott, Claus Eric, Grünhagen, Johannes, Jäger, Marten, Horbelt, Daniel, Schwill, Simon, Kallenbach, Klaus, Guo, Gao, Manke, Thomas, Knaus, Petra, Mundlos, Stefan, Robinson, Peter N.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031556/
https://www.ncbi.nlm.nih.gov/pubmed/21305018
http://dx.doi.org/10.1371/journal.pone.0016250

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031556/
https://www.ncbi.nlm.nih.gov/pubmed/21305018
http://dx.doi.org/10.1371/journal.pone.0016250

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