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History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico
Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary by geographic regions ranging from countries to neighborhoods. We examined the geographic variation of...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031579/ https://www.ncbi.nlm.nih.gov/pubmed/21304981 http://dx.doi.org/10.1371/journal.pone.0016513 |
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author | Via, Marc Gignoux, Christopher R. Roth, Lindsey A. Fejerman, Laura Galanter, Joshua Choudhry, Shweta Toro-Labrador, Gladys Viera-Vera, Jorge Oleksyk, Taras K. Beckman, Kenneth Ziv, Elad Risch, Neil Burchard, Esteban González Martínez-Cruzado, Juan Carlos |
author_facet | Via, Marc Gignoux, Christopher R. Roth, Lindsey A. Fejerman, Laura Galanter, Joshua Choudhry, Shweta Toro-Labrador, Gladys Viera-Vera, Jorge Oleksyk, Taras K. Beckman, Kenneth Ziv, Elad Risch, Neil Burchard, Esteban González Martínez-Cruzado, Juan Carlos |
author_sort | Via, Marc |
collection | PubMed |
description | Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary by geographic regions ranging from countries to neighborhoods. We examined the geographic variation of admixture across the island of Puerto Rico and the degree to which it could be explained by historic and social events. We analyzed a census-based sample of 642 Puerto Rican individuals that were genotyped for 93 ancestry informative markers (AIMs) to estimate African, European and Native American ancestry. Socioeconomic status (SES) data and geographic location were obtained for each individual. There was significant geographic variation of ancestry across the island. In particular, African ancestry demonstrated a decreasing East to West gradient that was partially explained by historical factors linked to the colonial sugar plantation system. SES also demonstrated a parallel decreasing cline from East to West. However, at a local level, SES and African ancestry were negatively correlated. European ancestry was strongly negatively correlated with African ancestry and therefore showed patterns complementary to African ancestry. By contrast, Native American ancestry showed little variation across the island and across individuals and appears to have played little social role historically. The observed geographic distributions of SES and genetic variation relate to historical social events and mating patterns, and have substantial implications for the design of studies in the recently admixed Puerto Rican population. More generally, our results demonstrate the importance of incorporating social and geographic data with genetics when studying contemporary admixed populations. |
format | Text |
id | pubmed-3031579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30315792011-02-08 History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico Via, Marc Gignoux, Christopher R. Roth, Lindsey A. Fejerman, Laura Galanter, Joshua Choudhry, Shweta Toro-Labrador, Gladys Viera-Vera, Jorge Oleksyk, Taras K. Beckman, Kenneth Ziv, Elad Risch, Neil Burchard, Esteban González Martínez-Cruzado, Juan Carlos PLoS One Research Article Contemporary genetic variation among Latin Americans human groups reflects population migrations shaped by complex historical, social and economic factors. Consequently, admixture patterns may vary by geographic regions ranging from countries to neighborhoods. We examined the geographic variation of admixture across the island of Puerto Rico and the degree to which it could be explained by historic and social events. We analyzed a census-based sample of 642 Puerto Rican individuals that were genotyped for 93 ancestry informative markers (AIMs) to estimate African, European and Native American ancestry. Socioeconomic status (SES) data and geographic location were obtained for each individual. There was significant geographic variation of ancestry across the island. In particular, African ancestry demonstrated a decreasing East to West gradient that was partially explained by historical factors linked to the colonial sugar plantation system. SES also demonstrated a parallel decreasing cline from East to West. However, at a local level, SES and African ancestry were negatively correlated. European ancestry was strongly negatively correlated with African ancestry and therefore showed patterns complementary to African ancestry. By contrast, Native American ancestry showed little variation across the island and across individuals and appears to have played little social role historically. The observed geographic distributions of SES and genetic variation relate to historical social events and mating patterns, and have substantial implications for the design of studies in the recently admixed Puerto Rican population. More generally, our results demonstrate the importance of incorporating social and geographic data with genetics when studying contemporary admixed populations. Public Library of Science 2011-01-31 /pmc/articles/PMC3031579/ /pubmed/21304981 http://dx.doi.org/10.1371/journal.pone.0016513 Text en Via et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Via, Marc Gignoux, Christopher R. Roth, Lindsey A. Fejerman, Laura Galanter, Joshua Choudhry, Shweta Toro-Labrador, Gladys Viera-Vera, Jorge Oleksyk, Taras K. Beckman, Kenneth Ziv, Elad Risch, Neil Burchard, Esteban González Martínez-Cruzado, Juan Carlos History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico |
title | History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico |
title_full | History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico |
title_fullStr | History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico |
title_full_unstemmed | History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico |
title_short | History Shaped the Geographic Distribution of Genomic Admixture on the Island of Puerto Rico |
title_sort | history shaped the geographic distribution of genomic admixture on the island of puerto rico |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031579/ https://www.ncbi.nlm.nih.gov/pubmed/21304981 http://dx.doi.org/10.1371/journal.pone.0016513 |
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