CYP1A1 Induction in the Colon by Serum: Involvement of the PPARα Pathway and Evidence for a New Specific Human PPREα Site

BACKGROUND: We previously showed that blood serum induced cytochrome P450 1A1 (CYP1A1) monooxygenase expression in vitro. OBJECTIVE: Our purpose was (i) to identify the molecular mechanism involved and (ii) to characterize the inducer compound(s) in serum involved at least in part. METHODS: Serum wa...

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Detalles Bibliográficos
Autores principales: Villard, Pierre-Henri, Barlesi, Fabrice, Armand, Martine, Dao, Thi-Mai-Anh, Pascussi, Jean-Marc, Fouchier, Francis, Champion, Serge, Dufour, Claire, Giniès, Christian, Khalil, Ayman, Amiot, Marie-Josephe, Barra, Yves, Seree, Eric
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031628/
https://www.ncbi.nlm.nih.gov/pubmed/21304969
http://dx.doi.org/10.1371/journal.pone.0014629

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