PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells

BACKGROUND: In recent years, much progress has been made in the treatment of multiple myeloma. However, a major limitation of existing chemotherapeutic drugs is the eventual emergence of resistance; hence, the development of novel agents with new mechanisms of action is pertinent. Here, we describe...

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Detalles Bibliográficos
Autores principales: Maginn, E N, Browne, P V, Hayden, P, Vandenberghe, E, MacDonagh, B, Evans, P, Goodyer, M, Tewari, P, Campiani, G, Butini, S, Williams, D C, Zisterer, D M, Lawler, M P, McElligott, A M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031893/
https://www.ncbi.nlm.nih.gov/pubmed/21179037
http://dx.doi.org/10.1038/sj.bjc.6606035

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