Cargando…

Diabetogenic glucose and insulin concentrations modulate transcriptom and protein levels involved in tumour cell migration, adhesion and proliferation

BACKGROUND: During the last decade, epidemiological studies uncovered the tremendous impact of metabolic syndrome/diabetes mellitus type 2 (DM T2) as risk factors of the progression of cancer. Therefore, we studied the impact of diabetogenic glucose and insulin concentrations on the activities of tu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Masur, K, Vetter, C, Hinz, A, Tomas, N, Henrich, H, Niggemann, B, Zänker, K S
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2011
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031898/ https://www.ncbi.nlm.nih.gov/pubmed/21179032 http://dx.doi.org/10.1038/sj.bjc.6606050

Ejemplares similares

Akt and phospholipase Cγ are involved in the regulation of growth and migration of MDA-MB-468 breast cancer and SW480 colon cancer cells when cultured with diabetogenic levels of glucose and insulin
por: Tomas, Nicola M, et al.
Publicado: (2012)

Migration rules: tumours are conglomerates of self-metastases
por: Enderling, H, et al.
Publicado: (2009)

Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts
por: Huhtinen, K, et al.
Publicado: (2009)

Circulating IL-6 concentrations link tumour necrosis and systemic and local inflammatory responses in patients undergoing resection for colorectal cancer
por: Guthrie, G J K, et al.
Publicado: (2013)

Mammary gland-specific ablation of focal adhesion kinase reduces the incidence of p53-mediated mammary tumour formation
por: van Miltenburg, M H A M, et al.
Publicado: (2014)

Potent anti-tumour activity of a novel conditionally replicating adenovirus for melanoma via inhibition of migration and invasion
por: Jiang, G, et al.
Publicado: (2014)

MicroRNA-211-5p suppresses tumour cell proliferation, invasion, migration and metastasis in triple-negative breast cancer by directly targeting SETBP1
por: Chen, Liang-liang, et al.
Publicado: (2017)

Isolation of tumour stem-like cells from benign tumours
por: Xu, Q, et al.
Publicado: (2009)

An expression signature of the angiogenic response in gastrointestinal neuroendocrine tumours: correlation with tumour phenotype and survival outcomes
por: Pinato, D J, et al.
Publicado: (2014)

Suppression of tumour growth by orally administered osteopontin is accompanied by alterations in tumour blood vessels
por: Rittling, S R, et al.
Publicado: (2014)

Increased expression of ALCAM/CD166 in pancreatic cancer is an independent prognostic marker for poor survival and early tumour relapse
por: Kahlert, C, et al.
Publicado: (2009)

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation
por: Sadanandam, A, et al.
Publicado: (2012)

Testosterone regulates cell proliferation in aggressive fibromatosis (desmoid tumour)
por: Hong, H, et al.
Publicado: (2011)

Monitoring gastric cancer progression with circulating tumour DNA
por: Hamakawa, T, et al.
Publicado: (2015)

c-FOS suppresses ovarian cancer progression by changing adhesion
por: Oliveira-Ferrer, L, et al.
Publicado: (2014)

Modified primary tumour/vessel tumour/nodal tumour classification for patients with invasive ductal carcinoma of the breast
por: Hasebe, T, et al.
Publicado: (2011)

Tumour-suppressive microRNA-29s inhibit cancer cell migration and invasion by targeting laminin–integrin signalling in head and neck squamous cell carcinoma
por: Kinoshita, T, et al.
Publicado: (2013)

Expression of a protease-resistant insulin-like growth factor-binding protein-4 inhibits tumour growth in a murine model of breast cancer
por: Ryan, A J, et al.
Publicado: (2009)

Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis
por: Osawa, T, et al.
Publicado: (2013)

Noncoding human Y RNAs are overexpressed in tumours and required for cell proliferation
por: Christov, C P, et al.
Publicado: (2008)

Independent and functional validation of a multi-tumour-type proliferation signature
por: Starmans, M H W, et al.
Publicado: (2012)

The in situ local immune response, tumour senescence and proliferation in colorectal cancer
por: Roxburgh, C S, et al.
Publicado: (2013)

Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies
por: Chaudhary, P, et al.
Publicado: (2014)

Diagnostic value of CA19.9, circulating tumour DNA and circulating tumour cells in patients with solid pancreatic tumours
por: Sefrioui, David, et al.
Publicado: (2017)

Objective assessment of tumour response to therapy based on tumour growth kinetics
por: Mehrara, E, et al.
Publicado: (2011)

Biglycan is a specific marker and an autocrine angiogenic factor of tumour endothelial cells
por: Yamamoto, K, et al.
Publicado: (2012)

The relationship between tumour necrosis, tumour proliferation, local and systemic inflammation, microvessel density and survival in patients undergoing potentially curative resection of oesophageal adenocarcinoma
por: Dutta, S, et al.
Publicado: (2012)

Disseminated tumour cells as a prognostic biomarker in colorectal cancer
por: Flatmark, K, et al.
Publicado: (2011)

Involvement of dysadherin and E-cadherin in the development of testicular tumours
por: Batistatou, A, et al.
Publicado: (2005)

Comparison of bone marrow, disseminated tumour cells and blood-circulating tumour cells in breast cancer patients after primary treatment
por: Slade, M J, et al.
Publicado: (2009)

PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness
por: Molleví, D G, et al.
Publicado: (2008)

Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression
por: Couvelard, A, et al.
Publicado: (2005)

Dichloroacetate induces autophagy in colorectal cancer cells and tumours
por: Lin, G, et al.
Publicado: (2014)

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype
por: Ameri, K, et al.
Publicado: (2010)

Tumour epithelial vimentin expression and outcome of pancreatic ductal adenocarcinomas
por: Handra-Luca, A, et al.
Publicado: (2011)

Activin A inhibits vascular endothelial cell growth and suppresses tumour angiogenesis in gastric cancer
por: Kaneda, H, et al.
Publicado: (2011)

Clinical significance of disseminated tumour cells in non-small cell lung cancer
por: Rud, A K, et al.
Publicado: (2013)

Monitoring of circulating tumour-associated DNA as a prognostic tool for oral squamous cell carcinoma
por: Hamana, K, et al.
Publicado: (2005)

G-CSF and G-CSFR are highly expressed in human gastric and colon cancers and promote carcinoma cell proliferation and migration
por: Morris, K T, et al.
Publicado: (2014)

Endothelin B receptor expression correlates with tumour angiogenesis and prognosis in oesophageal squamous cell carcinoma
por: Tanaka, T, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_n6aepejf3dtsi8s0rm7op1glov