Attenuated reovirus displays oncolysis with reduced host toxicity

BACKGROUND: Although the naturally occurring reovirus causes only mild symptoms in humans, it shows considerable potential as an oncolytic agent because of its innate ability to target cancer cells. In immunocompromised hosts, however, wild-type reovirus can target healthy tissues, including heart,...

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Detalles Bibliográficos
Autores principales: Kim, M, Garant, K A, zur Nieden, N I, Alain, T, Loken, S D, Urbanski, S J, Forsyth, P A, Rancourt, D E, Lee, P W K, Johnston, R N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031901/
https://www.ncbi.nlm.nih.gov/pubmed/21179029
http://dx.doi.org/10.1038/sj.bjc.6606053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031901/
https://www.ncbi.nlm.nih.gov/pubmed/21179029
http://dx.doi.org/10.1038/sj.bjc.6606053

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