Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

To be effective, therapeutic compounds must typically enter target cells and, in some cases, must be concentrated or modified. Thus, uptake and activation mechanisms often form the basis of selectivity against infectious agents. Loss-of-function screens can be used to identify proteins involved in d...

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Detalles Bibliográficos
Autores principales: Baker, Nicola, Alsford, Sam, Horn, David
Formato: Texto
Lenguaje:English
Publicado: Elsevier/North-Holland Biomedical Press 2011
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032052/
https://www.ncbi.nlm.nih.gov/pubmed/21093499
http://dx.doi.org/10.1016/j.molbiopara.2010.11.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032052/
https://www.ncbi.nlm.nih.gov/pubmed/21093499
http://dx.doi.org/10.1016/j.molbiopara.2010.11.010

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