Obatoclax induces Atg7-dependent autophagy independent of beclin-1 and BAX/BAK

Direct pharmacological targeting of the anti-apoptotic B-cell lymphoma-2 (BCL-2) family is an attractive therapeutic strategy for treating cancer. Obatoclax is a pan-BCL-2 family inhibitor currently in clinical development. Here we show that, although obatoclax can induce mitochondrial apoptosis dep...

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Detalles Bibliográficos
Autores principales: McCoy, F, Hurwitz, J, McTavish, N, Paul, I, Barnes, C, O'Hagan, B, Odrzywol, K, Murray, J, Longley, D, McKerr, G, Fennell, D A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032298/
https://www.ncbi.nlm.nih.gov/pubmed/21368880
http://dx.doi.org/10.1038/cddis.2010.86

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