Apoptosis of human melanoma cells induced by inhibition of B-RAF(V600E) involves preferential splicing of bim(S)

Bim is known to be critical in killing of melanoma cells by inhibition of the RAF/MEK/ERK pathway. However, the potential role of the most potent apoptosis-inducing isoform of Bim, Bim(S), remains largely unappreciated. Here, we show that inhibition of the mutant B-RAF(V600E) triggers preferential s...

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Detalles Bibliográficos
Autores principales: Jiang, C C, Lai, F, Tay, K H, Croft, A, Rizos, H, Becker, T M, Yang, F, Liu, H, Thorne, R F, Hersey, P, Zhang, X D
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032346/
https://www.ncbi.nlm.nih.gov/pubmed/21364673
http://dx.doi.org/10.1038/cddis.2010.48

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