Intracellular Ca(2+) release through ryanodine receptors contributes to AMPA receptor-mediated mitochondrial dysfunction and ER stress in oligodendrocytes

Overactivation of ionotropic glutamate receptors in oligodendrocytes induces cytosolic Ca(2+) overload and excitotoxic death, a process that contributes to demyelination and multiple sclerosis. Excitotoxic insults cause well-characterized mitochondrial alterations and endoplasmic reticulum (ER) dysf...

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Detalles Bibliográficos
Autores principales: Ruiz, A, Matute, C, Alberdi, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032558/
https://www.ncbi.nlm.nih.gov/pubmed/21364659
http://dx.doi.org/10.1038/cddis.2010.31

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