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Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study
BACKGROUND: Coronary artery calcification (CAC) has been proposed to be the underlying mechanism of the increased risk of coronary heart disease with reductions in glomerular filtration rate (GFR). Since renal function diminishes with aging we examined the association between GFR and CAC in the Rott...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032739/ https://www.ncbi.nlm.nih.gov/pubmed/21311747 http://dx.doi.org/10.1371/journal.pone.0016738 |
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author | el Barzouhi, Abdelilah Elias-Smale, Suzette Dehghan, Abbas Vliegenthart-Proença, Rozemarijn Oudkerk, Matthijs Hofman, Albert Witteman, Jacqueline C. M. |
author_facet | el Barzouhi, Abdelilah Elias-Smale, Suzette Dehghan, Abbas Vliegenthart-Proença, Rozemarijn Oudkerk, Matthijs Hofman, Albert Witteman, Jacqueline C. M. |
author_sort | el Barzouhi, Abdelilah |
collection | PubMed |
description | BACKGROUND: Coronary artery calcification (CAC) has been proposed to be the underlying mechanism of the increased risk of coronary heart disease with reductions in glomerular filtration rate (GFR). Since renal function diminishes with aging we examined the association between GFR and CAC in the Rotterdam Study, a population-based study of elderly individuals. METHODS: The study was performed in 1703 subjects without a history of coronary heart disease. GFR was estimated using the modification of diet in renal disease equation. We used analysis of covariance to test for mean differences in CAC between GFR tertiles. RESULTS: The mean CAC scores in the middle and lowest GFR tertile did not significantly differ from the mean CAC score in the highest GFR tertile (geometric mean CAC score 4.1 and 4.3 vs 4.2). In a multivariable model the mean CAC score did also not differ between the GFR tertiles. As the interaction term between age and GFR was significant (P = 0.037), we divided the population in two age categories based on median age of 70 years. Below 70 years, the mean CAC scores did not differ between the GFR tertiles. Above median age, mean CAC score in the lowest GFR tertile was significantly higher than the mean CAC score in the highest tertile in a multivariable model (CAC 4.9 vs 4.5, p = 0.010). CONCLUSION: In this population-based study we observed that the association between CAC and GFR is modified by age. In participants at least 70 years of age, a decrease in GFR was associated with increased CAC. |
format | Text |
id | pubmed-3032739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-30327392011-02-10 Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study el Barzouhi, Abdelilah Elias-Smale, Suzette Dehghan, Abbas Vliegenthart-Proença, Rozemarijn Oudkerk, Matthijs Hofman, Albert Witteman, Jacqueline C. M. PLoS One Research Article BACKGROUND: Coronary artery calcification (CAC) has been proposed to be the underlying mechanism of the increased risk of coronary heart disease with reductions in glomerular filtration rate (GFR). Since renal function diminishes with aging we examined the association between GFR and CAC in the Rotterdam Study, a population-based study of elderly individuals. METHODS: The study was performed in 1703 subjects without a history of coronary heart disease. GFR was estimated using the modification of diet in renal disease equation. We used analysis of covariance to test for mean differences in CAC between GFR tertiles. RESULTS: The mean CAC scores in the middle and lowest GFR tertile did not significantly differ from the mean CAC score in the highest GFR tertile (geometric mean CAC score 4.1 and 4.3 vs 4.2). In a multivariable model the mean CAC score did also not differ between the GFR tertiles. As the interaction term between age and GFR was significant (P = 0.037), we divided the population in two age categories based on median age of 70 years. Below 70 years, the mean CAC scores did not differ between the GFR tertiles. Above median age, mean CAC score in the lowest GFR tertile was significantly higher than the mean CAC score in the highest tertile in a multivariable model (CAC 4.9 vs 4.5, p = 0.010). CONCLUSION: In this population-based study we observed that the association between CAC and GFR is modified by age. In participants at least 70 years of age, a decrease in GFR was associated with increased CAC. Public Library of Science 2011-02-02 /pmc/articles/PMC3032739/ /pubmed/21311747 http://dx.doi.org/10.1371/journal.pone.0016738 Text en el Barzouhi et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article el Barzouhi, Abdelilah Elias-Smale, Suzette Dehghan, Abbas Vliegenthart-Proença, Rozemarijn Oudkerk, Matthijs Hofman, Albert Witteman, Jacqueline C. M. Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study |
title | Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study |
title_full | Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study |
title_fullStr | Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study |
title_full_unstemmed | Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study |
title_short | Renal Function Is Related to Severity of Coronary Artery Calcification in Elderly Persons: The Rotterdam Study |
title_sort | renal function is related to severity of coronary artery calcification in elderly persons: the rotterdam study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032739/ https://www.ncbi.nlm.nih.gov/pubmed/21311747 http://dx.doi.org/10.1371/journal.pone.0016738 |
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