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Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review
BACKGROUND: Hyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear. METHODS: We undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound heali...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032900/ https://www.ncbi.nlm.nih.gov/pubmed/21184071 http://dx.doi.org/10.1007/s00268-010-0923-4 |
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author | Eskes, Anne M. Ubbink, Dirk T. Lubbers, Maarten J. Lucas, Cees Vermeulen, Hester |
author_facet | Eskes, Anne M. Ubbink, Dirk T. Lubbers, Maarten J. Lucas, Cees Vermeulen, Hester |
author_sort | Eskes, Anne M. |
collection | PubMed |
description | BACKGROUND: Hyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear. METHODS: We undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound healing and adverse effects in patients with acute wounds. To detect all available randomized controlled trials (RCTs) we searched five relevant databases up to March 2010. Trial selection, quality assessment, data extraction, and data synthesis were conducted by two of the authors independently. RESULTS: We included five trials, totaling 360 patients. These trials, with some methodologic flaws, included different kinds of wound and focused on different outcome parameters, which prohibited meta-analysis. A French trial (n = 36 patients) reported that significantly more crush wounds healed with HBOT than with sham HBOT [relative risk (RR) 1.70, 95% confidence interval (CI) 1.11–2.61]. Moreover, there were significantly fewer additional surgical procedures required with HBOT (RR 1.60, 95% CI 1.03–2.50), and there was significantly less tissue necrosis (RR 1.70, 95% CI 1.11–2.61). In one of two American trials (n = 141) burn wounds healed significantly quicker with HBOT (P < 0.005) than with routine burn care. A British trial (n = 48) compared HBOT with usual care. HBOT resulted in a significantly higher percentage of healthy graft area in split skin grafts (RR 3.50, 95% CI 1.35–9.11). In a Chinese trial (n = 145) HBOT did not significantly improve flap survival in patients with limb skin defects. CONCLUSIONS: HBOT, if readily available, appears effective for the management of acute, difficult to heal wounds. |
format | Text |
id | pubmed-3032900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-30329002011-03-16 Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review Eskes, Anne M. Ubbink, Dirk T. Lubbers, Maarten J. Lucas, Cees Vermeulen, Hester World J Surg Article BACKGROUND: Hyperbaric oxygen therapy (HBOT) is used to treat various wound types. However, the possible beneficial and harmful effects of HBOT for acute wounds are unclear. METHODS: We undertook a systematic review to evaluate the effectiveness of HBOT compared to other interventions on wound healing and adverse effects in patients with acute wounds. To detect all available randomized controlled trials (RCTs) we searched five relevant databases up to March 2010. Trial selection, quality assessment, data extraction, and data synthesis were conducted by two of the authors independently. RESULTS: We included five trials, totaling 360 patients. These trials, with some methodologic flaws, included different kinds of wound and focused on different outcome parameters, which prohibited meta-analysis. A French trial (n = 36 patients) reported that significantly more crush wounds healed with HBOT than with sham HBOT [relative risk (RR) 1.70, 95% confidence interval (CI) 1.11–2.61]. Moreover, there were significantly fewer additional surgical procedures required with HBOT (RR 1.60, 95% CI 1.03–2.50), and there was significantly less tissue necrosis (RR 1.70, 95% CI 1.11–2.61). In one of two American trials (n = 141) burn wounds healed significantly quicker with HBOT (P < 0.005) than with routine burn care. A British trial (n = 48) compared HBOT with usual care. HBOT resulted in a significantly higher percentage of healthy graft area in split skin grafts (RR 3.50, 95% CI 1.35–9.11). In a Chinese trial (n = 145) HBOT did not significantly improve flap survival in patients with limb skin defects. CONCLUSIONS: HBOT, if readily available, appears effective for the management of acute, difficult to heal wounds. Springer-Verlag 2010-12-24 2011 /pmc/articles/PMC3032900/ /pubmed/21184071 http://dx.doi.org/10.1007/s00268-010-0923-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Eskes, Anne M. Ubbink, Dirk T. Lubbers, Maarten J. Lucas, Cees Vermeulen, Hester Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review |
title | Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review |
title_full | Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review |
title_fullStr | Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review |
title_full_unstemmed | Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review |
title_short | Hyperbaric Oxygen Therapy: Solution for Difficult to Heal Acute Wounds? Systematic Review |
title_sort | hyperbaric oxygen therapy: solution for difficult to heal acute wounds? systematic review |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032900/ https://www.ncbi.nlm.nih.gov/pubmed/21184071 http://dx.doi.org/10.1007/s00268-010-0923-4 |
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