In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)

In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three pos...

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Detalles Bibliográficos
Autores principales: Renda, Maria Concetta, Maggio, Aurelio
Formato: Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2009
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033157/
https://www.ncbi.nlm.nih.gov/pubmed/21415998
http://dx.doi.org/10.4084/MJHID.2009.031
Descripción
Sumario:In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three possible barriers to engraftment following IUHSCT: limited space in the fetus due to host-cell competition; the large number of donor cells needed, and the immunological asset of recipient.

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