In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)

In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three pos...

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Detalles Bibliográficos
Autores principales: Renda, Maria Concetta, Maggio, Aurelio
Formato: Texto
Lenguaje:English
Publicado: Università Cattolica del Sacro Cuore 2009
Materias:
Perspectives
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033157/
https://www.ncbi.nlm.nih.gov/pubmed/21415998
http://dx.doi.org/10.4084/MJHID.2009.031
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author Renda, Maria Concetta
Maggio, Aurelio
author_facet Renda, Maria Concetta
Maggio, Aurelio
author_sort Renda, Maria Concetta
collection PubMed
description In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three possible barriers to engraftment following IUHSCT: limited space in the fetus due to host-cell competition; the large number of donor cells needed, and the immunological asset of recipient.
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spelling pubmed-30331572011-03-17 In Utero Haematopoietic Stem Cell Transplantation (IUHSCT) Renda, Maria Concetta Maggio, Aurelio Mediterr J Hematol Infect Dis Perspectives In utero haematopoietic stem cell transplantation (IUHSCT) is a non-myeloablative approach for the prenatal treatment of genetic disorders. However, in target disorders, where there is not a selective advantage for donor cells, a useful donor-cell chimerism has not been achieved. There are three possible barriers to engraftment following IUHSCT: limited space in the fetus due to host-cell competition; the large number of donor cells needed, and the immunological asset of recipient. Università Cattolica del Sacro Cuore 2009-12-29 /pmc/articles/PMC3033157/ /pubmed/21415998 http://dx.doi.org/10.4084/MJHID.2009.031 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Perspectives
Renda, Maria Concetta
Maggio, Aurelio
In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)
title In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)
title_full In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)
title_fullStr In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)
title_full_unstemmed In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)
title_short In Utero Haematopoietic Stem Cell Transplantation (IUHSCT)
title_sort in utero haematopoietic stem cell transplantation (iuhsct)
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033157/
https://www.ncbi.nlm.nih.gov/pubmed/21415998
http://dx.doi.org/10.4084/MJHID.2009.031
work_keys_str_mv AT rendamariaconcetta inuterohaematopoieticstemcelltransplantationiuhsct
AT maggioaurelio inuterohaematopoieticstemcelltransplantationiuhsct

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