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Urethral metastasis from non-seminomatous germ cell tumor: a case report

INTRODUCTION: We present a case of nonseminomatous germ cell tumor of the testes with acute urinary retention secondary to urethral metastasis. This presentation, and similar cases of urethral metastasis from this tumor, have not been reported previously. CASE PRESENTATION: A 35-year-old Caucasian m...

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Autores principales: Agarwal, Vijay, Wah, Tze, Chilka, Sameer, Joffe, Johnathan, Stark, Dan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033347/
https://www.ncbi.nlm.nih.gov/pubmed/21241492
http://dx.doi.org/10.1186/1752-1947-5-12
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author Agarwal, Vijay
Wah, Tze
Chilka, Sameer
Joffe, Johnathan
Stark, Dan
author_facet Agarwal, Vijay
Wah, Tze
Chilka, Sameer
Joffe, Johnathan
Stark, Dan
author_sort Agarwal, Vijay
collection PubMed
description INTRODUCTION: We present a case of nonseminomatous germ cell tumor of the testes with acute urinary retention secondary to urethral metastasis. This presentation, and similar cases of urethral metastasis from this tumor, have not been reported previously. CASE PRESENTATION: A 35-year-old Caucasian man presented to hospital with a history of acute urinary retention. On examination he was found to have right testicular enlargement with raised β-human chorionic gonadotrophin, serum α-fetoprotein and lactate dehydrogenase levels. He underwent radical left inguinal orchidectomy and histology confirmed a nonseminomatous germ cell tumor of the testes. Cystoscopy carried out due to urinary retention showed penile metastasis and the biopsy confirmed metastatic malignant undifferentiated teratoma. Staging computed tomography scan and magnetic resonance imaging of the pelvis showed pulmonary, pelvic nodal, ischial and penile metastasis. The diagnosis of the International Germ Cell Cancer Collaborative Group of poor prognosis metastatic nonseminomatous germ cell tumor was made, following which he received four cycles of bleomycin, etoposide and cisplatin chemotherapy with curative intent. He had a complete marker and an excellent radiological response. He is currently under follow up. CONCLUSION: The unusual presentation of lymphovascular spread in this case of nonseminomatous germ cell tumor highlights the need to include routine pelvic imaging in the assessment and follow up of testicular cancer.
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spelling pubmed-30333472011-02-04 Urethral metastasis from non-seminomatous germ cell tumor: a case report Agarwal, Vijay Wah, Tze Chilka, Sameer Joffe, Johnathan Stark, Dan J Med Case Reports Case Report INTRODUCTION: We present a case of nonseminomatous germ cell tumor of the testes with acute urinary retention secondary to urethral metastasis. This presentation, and similar cases of urethral metastasis from this tumor, have not been reported previously. CASE PRESENTATION: A 35-year-old Caucasian man presented to hospital with a history of acute urinary retention. On examination he was found to have right testicular enlargement with raised β-human chorionic gonadotrophin, serum α-fetoprotein and lactate dehydrogenase levels. He underwent radical left inguinal orchidectomy and histology confirmed a nonseminomatous germ cell tumor of the testes. Cystoscopy carried out due to urinary retention showed penile metastasis and the biopsy confirmed metastatic malignant undifferentiated teratoma. Staging computed tomography scan and magnetic resonance imaging of the pelvis showed pulmonary, pelvic nodal, ischial and penile metastasis. The diagnosis of the International Germ Cell Cancer Collaborative Group of poor prognosis metastatic nonseminomatous germ cell tumor was made, following which he received four cycles of bleomycin, etoposide and cisplatin chemotherapy with curative intent. He had a complete marker and an excellent radiological response. He is currently under follow up. CONCLUSION: The unusual presentation of lymphovascular spread in this case of nonseminomatous germ cell tumor highlights the need to include routine pelvic imaging in the assessment and follow up of testicular cancer. BioMed Central 2011-01-17 /pmc/articles/PMC3033347/ /pubmed/21241492 http://dx.doi.org/10.1186/1752-1947-5-12 Text en Copyright ©2011 Agarwal et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Agarwal, Vijay
Wah, Tze
Chilka, Sameer
Joffe, Johnathan
Stark, Dan
Urethral metastasis from non-seminomatous germ cell tumor: a case report
title Urethral metastasis from non-seminomatous germ cell tumor: a case report
title_full Urethral metastasis from non-seminomatous germ cell tumor: a case report
title_fullStr Urethral metastasis from non-seminomatous germ cell tumor: a case report
title_full_unstemmed Urethral metastasis from non-seminomatous germ cell tumor: a case report
title_short Urethral metastasis from non-seminomatous germ cell tumor: a case report
title_sort urethral metastasis from non-seminomatous germ cell tumor: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033347/
https://www.ncbi.nlm.nih.gov/pubmed/21241492
http://dx.doi.org/10.1186/1752-1947-5-12
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AT chilkasameer urethralmetastasisfromnonseminomatousgermcelltumoracasereport
AT joffejohnathan urethralmetastasisfromnonseminomatousgermcelltumoracasereport
AT starkdan urethralmetastasisfromnonseminomatousgermcelltumoracasereport