SOD2 Deficient Erythroid Cells Up-Regulate Transferrin Receptor and Down-Regulate Mitochondrial Biogenesis and Metabolism

BACKGROUND: Mice irradiated and reconstituted with hematopoietic cells lacking manganese superoxide dismutase (SOD2) show a persistent hemolytic anemia similar to human sideroblastic anemia (SA), including characteristic intra-mitochondrial iron deposition. SA is primarily an acquired, clonal marrow...

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Detalles Bibliográficos
Autores principales: Martin, Florent M., Xu, Xiuling, von Löhneysen, Katharina, Gilmartin, Timothy J., Friedman, Jeffrey S.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033911/
https://www.ncbi.nlm.nih.gov/pubmed/21326867
http://dx.doi.org/10.1371/journal.pone.0016894

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