The DNA damage response: Balancing the scale between cancer and ageing

Defects in the DNA damage response often lead to an increased susceptibility to cancer, and so the DDR presents an interesting set of novel therapeutic targets. The maintenance of genomic integrity by the DDR has also been found to be involved in the process of organismal ageing. While the removal o...

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Detalles Bibliográficos
Autores principales: Seviour, Elena G., Lin, Shiaw-Yih
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034178/
https://www.ncbi.nlm.nih.gov/pubmed/21191148
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author Seviour, Elena G.
Lin, Shiaw-Yih
author_facet Seviour, Elena G.
Lin, Shiaw-Yih
author_sort Seviour, Elena G.
collection PubMed
description Defects in the DNA damage response often lead to an increased susceptibility to cancer, and so the DDR presents an interesting set of novel therapeutic targets. The maintenance of genomic integrity by the DDR has also been found to be involved in the process of organismal ageing. While the removal of cells containing damaged DNA can be beneficial in the prevention of cancer, it may contribute to both normal and pathological ageing.
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spelling pubmed-30341782011-02-08 The DNA damage response: Balancing the scale between cancer and ageing Seviour, Elena G. Lin, Shiaw-Yih Aging (Albany NY) Review Defects in the DNA damage response often lead to an increased susceptibility to cancer, and so the DDR presents an interesting set of novel therapeutic targets. The maintenance of genomic integrity by the DDR has also been found to be involved in the process of organismal ageing. While the removal of cells containing damaged DNA can be beneficial in the prevention of cancer, it may contribute to both normal and pathological ageing. Impact Journals LLC 2010-12-16 /pmc/articles/PMC3034178/ /pubmed/21191148 Text en Copyright: © 2010 Seviour and Lin http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Review
Seviour, Elena G.
Lin, Shiaw-Yih
The DNA damage response: Balancing the scale between cancer and ageing
title The DNA damage response: Balancing the scale between cancer and ageing
title_full The DNA damage response: Balancing the scale between cancer and ageing
title_fullStr The DNA damage response: Balancing the scale between cancer and ageing
title_full_unstemmed The DNA damage response: Balancing the scale between cancer and ageing
title_short The DNA damage response: Balancing the scale between cancer and ageing
title_sort dna damage response: balancing the scale between cancer and ageing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3034178/
https://www.ncbi.nlm.nih.gov/pubmed/21191148
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